Evidence map›Paper›PMID 32957939›Full record

ArticleRespiratory research2020

Airway nitrite is increased in extremely preterm infants with bronchopulmonary dysplasia.

Samuel J Gentle, Amelia Freeman, Rakesh P Patel, Namasivayam Ambalavanan, Charitharth V Lal

Open access · goldAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Respiratory research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Samuel J GentleDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 1700 6th Ave S, Birmingham, al, 35233, USA. sjgentle@uabmc.edu.ORCID http://orcid.org/0000-0003-0238-6472
Amelia FreemanDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 1700 6th Ave S, Birmingham, al, 35233, USA.
Rakesh P PatelDepartment of Pathology and Center for Free Radical Biology, University of Alabama at Birmingham, Birmingham, USA.
Namasivayam AmbalavananDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 1700 6th Ave S, Birmingham, al, 35233, USA.
Charitharth V LalDivision of Neonatology, Department of Pediatrics, University of Alabama at Birmingham, 1700 6th Ave S, Birmingham, al, 35233, USA.
University of Alabama at Birmingham · US

Funding

UAB CF Research and Translation Core CenterP30DK072482 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMIT GAGGAR · 2007 to 2026
$23.0M
TRANSFORMING GROWTH FACTOR - BETA MEDIATES EFFECTS OF HYPOXIA IN NEWBORN LUNGR01HL092906 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI AMBALAVANAN, NAMASIVAYAM · 2008 to 2012
$1.9M
Mechanisms of Pulmonary Microbiota-Induced Inflammation and Vascular Dysfunction in Neonatal Lung InjuryK08HL141652 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LAL, CHARITHARTH VIVEK · 2019 to 2023
$838k
Oral nitrate metabolism as a predictor for bronchopulmonary in preterm infantsR21HD100917 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI GENTLE, SAMUEL J, PATEL, RAKESH P. · 2020 to 2021
$408k
American Heart Association AHA 17SDG32720009National Institute of Child Health and Human Development R21 HD100917-01NHLBI NIH HHS K08 HL141652NHLBI NIH HHS NHLBI K08HL141652NHLBI NIH HHS NHLBI R01 HL092906NHLBI NIH HHS R01 HL092906NICHD NIH HHS R21 HD100917NIDDK NIH HHS P30 DK072482
6 · The paper itself

Abstract

rationaleBronchopulmonary dysplasia (BPD) is the most common complication of prematurity and significantly contributes to mortality and morbidity with few predictive biomarkers. Given that nitrites have been implicated in pathways associated with lung disease, we hypothesized that nitrite levels would be altered in the airways of premature infants diagnosed with BPD.

methodsThis was a prospective cohort study of extremely low birth infants (< 28 weeks' gestation) at the University of Alabama at Birmingham. Nitrite levels from tracheal aspirates (TAs) were compared between intubated and ventilated infants with BPD and gestation matched full term (FT) controls. TA derived nitrite levels from day one after birth were also compared between preterm infants who did and did not develop BPD.

resultsInfants with BPD were found to have significantly elevated nitrite levels in their tracheal aspirates compared to gestation matched FT controls (p < 0.05). There was a trend for increased nitrite levels on postnatal day one in infants that developed BPD compared to infants that did not develop BPD (p = 0.05).

conclusionsIn conclusion, nitrite levels are significantly increased in airways of infants with BPD. Data from a larger cohort are needed to further support the utility of nitrite for BPD prediction.

trial registrationNot applicable.

Indexed as

Bronchopulmonary DysplasiaCohort StudiesFemaleHumansInfant, Extremely PrematureInfant, NewbornMaleNitritesProspective StudiesTracheaNitritesBronchopulmonary dysplasiaNitric oxideNitritePreterm infants

Identifiers

PMID32957939
PMCPMC7504869
OpenAlexW3087309755

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.