Evidence map›Paper›PMID 32957621›Full record

ArticleInternational journal of molecular sciences2020

Sex-Specific Effects of Microglia-Like Cell Engraftment during Experimental Autoimmune Encephalomyelitis.

Jinming Han, Keying Zhu, Kai Zhou, Ramil Hakim, Sreenivasa Raghavan Sankavaram, Klas Blomgren, Harald Lund, Xing-Mei Zhang, Robert A Harris

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 13 citations in OpenAlex.

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  8. Three novel mutations in Chinese patients withAnnals of translational medicine · 2021
    Article
  9. Uncovering sex differences of rodent microglia.Journal of neuroinflammation · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Jinming HanApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.ORCID 0000-0002-6084-3275
Keying ZhuApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.ORCID 0000-0001-7500-1532
Kai ZhouDepartment of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Ramil HakimDepartment of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Sreenivasa Raghavan SankavaramDepartment of Clinical Neuroscience, Karolinska Institutet, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Klas BlomgrenDepartment of Women's and Children's Health, Karolinska Institute, Karolinska University Hospital, S-171 76 Stockholm, Sweden.ORCID 0000-0002-0476-7271
Harald LundApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.ORCID 0000-0001-8046-0805
Xing-Mei ZhangApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.
Robert A HarrisApplied Immunology and Immunotherapy, Department of Clinical Neuroscience, Karolinska Institutet, Center for Molecular Medicine, Karolinska University Hospital, S-171 76 Stockholm, Sweden.ORCID 0000-0003-4990-509X
Karolinska University Hospital · SE

Funding

Alltid Litt Stekere not applicableAlzheimerFonden not applicableBarnCancerFonden not applicableChina Scholarship Council 201600160072 and 201700260280HjärnFonden not applicableNeuroforbundet not applicablethe Swedish Medical Research Council not applicable
6 · The paper itself

Abstract

Multiple sclerosis (MS) is a chronic neuroinflammatory disorder of the central nervous system (CNS) that usually presents in young adults and predominantly in females. Microglia, a major resident immune cell in the CNS, are critical players in both CNS homeostasis and disease. We have previously demonstrated that microglia can be efficiently depleted by the administration of tamoxifen in

Indexed as

AnimalsCentral Nervous SystemCytokinesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalFemaleHistocompatibility Antigens Class IIMacrophage ActivationMacrophagesMaleMiceMice, Inbred C57BLMice, KnockoutMicrogliaMonocytesMultiple SclerosisCytokinesHistocompatibility Antigens Class IIMyelin-Oligodendrocyte GlycoproteinTamoxifenexperimental autoimmune encephalomyelitismicrogliamicroglial repopulationmonocytesneuroinflammation

Identifiers

PMID32957621
PMCPMC7555782
OpenAlexW3086175049

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.