Evidence map›Paper›PMID 32957584›Full record

ReviewCells2020

Incorporating Prognostic Biomarkers into Risk Assessment Models and TNM Staging for Prostate Cancer.

Ragheed Saoud, Nassib Abou Heidar, Alessia Cimadamore, Gladell P Paner

Open access · goldAbstract readReview
In one paragraph

Review in Cells, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Ragheed SaoudDepartment of Surgery (Section of Urology), University of Chicago, Chicago, IL 60637, USA.ORCID 0000-0003-0210-9336
Nassib Abou HeidarDepartment of Surgery (Division of Urology), American University of Beirut Medical Center, Beirut 11-0236, Lebanon.ORCID 0000-0003-3811-5543
Alessia CimadamoreSection of Pathological Anatomy, Polytechnic University of the Marche Region, School of Medicine, 60126 Ancona, Italy.ORCID 0000-0001-5981-3514
Gladell P PanerDepartment of Surgery (Section of Urology), University of Chicago, Chicago, IL 60637, USA.
University of Chicago · USAmerican University of Beirut Medical Center · LBMarche Polytechnic University · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In current practice, prostate cancer staging alone is not sufficient to adequately assess the patient's prognosis and plan the management strategies. Multiple clinicopathological parameters and risk tools for prostate cancer have been developed over the past decades to better characterize the disease and provide an enhanced assessment of prognosis. Herein, we review novel prognostic biomarkers and their integration into risk assessment models for prostate cancer focusing on their capability to help avoid unnecessary imaging studies, biopsies and diagnosis of low risk prostate cancers, to help in the decision-making process between active surveillance and treatment intervention, and to predict recurrence after radical prostatectomy. There is an imperative need of reliable biomarkers to stratify prostate cancer patients that may benefit from different management approaches. The integration of biomarkers panel with risk assessment models appears to improve prostate cancer diagnosis and management. However, integration of novel genomic biomarkers in future prognostic models requires further validation in their clinical efficacy, standardization, and cost-effectiveness in routine application.

Indexed as

Disease ManagementModels, StatisticalAntigens, NeoplasmBiomarkers, TumorClinical Decision-MakingGene ExpressionHumansKallikreinsMaleNeoplasm ProteinsNeoplasm Recurrence, LocalNeoplasm StagingPrognosisProstateProstatectomyProstate-Specific AntigenAntigens, NeoplasmBiomarkers, TumorKallikreinsKLK3 protein, humanNeoplasm Proteinsprostate cancer antigen 3, humanProstate-Specific Antigenbiomarkersmolecular classifierpredictive scoresprognosisprostate cancerrisk assessment modelsstaging

Identifiers

PMID32957584
PMCPMC7564222
OpenAlexW3086919334

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.