Evidence map›Paper›PMID 32957563›Full record

ArticleMicromachines2020

A Tumbling Magnetic Microrobot System for Biomedical Applications.

Elizabeth E Niedert, Chenghao Bi, Georges Adam, Elly Lambert, Luis Solorio, Craig J Goergen, David J Cappelleri

Open access · goldAbstract read
In one paragraph

Article in Micromachines, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
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  5. Novel design of 3D printed tumbling microrobots for in vivo targeted drug delivery.Journal of controlled release : official journal of the Controlled Release Society · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Elizabeth E NiedertWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Chenghao BiSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Georges AdamSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0002-2307-3785
Elly LambertWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Luis SolorioWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0003-0135-8728
Craig J GoergenWeldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-8883-7953
David J CappelleriSchool of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USA.ORCID 0000-0001-7222-0625
Purdue University West Lafayette · US

Funding

Prescription Opioid Formulation to Deter Extraction, Injection, Insufflation, and SmokingR21DA048074 · NIDA · PURDUE UNIVERSITY · PI SOLORIO, LUIS · 2019 to 2020
$420k
National Science Foundation IIS 1358446National Science Foundation NRI 1637961NCI NIH HHS R0CA19829NIDA NIH HHS R21 DA048074
6 · The paper itself

Abstract

A microrobot system comprising an untethered tumbling magnetic microrobot, a two-degree-of-freedom rotating permanent magnet, and an ultrasound imaging system has been developed for in vitro and in vivo biomedical applications. The microrobot tumbles end-over-end in a net forward motion due to applied magnetic torque from the rotating magnet. By turning the rotational axis of the magnet, two-dimensional directional control is possible and the microrobot was steered along various trajectories, including a circular path and P-shaped path. The microrobot is capable of moving over the unstructured terrain within a murine colon in in vitro, in situ, and in vivo conditions, as well as a porcine colon in ex vivo conditions. High-frequency ultrasound imaging allows for real-time determination of the microrobot's position while it is optically occluded by animal tissue. When coated with a fluorescein payload, the microrobot was shown to release the majority of the payload over a 1-h time period in phosphate-buffered saline. Cytotoxicity tests demonstrated that the microrobot's constituent materials, SU-8 and polydimethylsiloxane (PDMS), did not show a statistically significant difference in toxicity to murine fibroblasts from the negative control, even when the materials were doped with magnetic neodymium microparticles. The microrobot system's capabilities make it promising for targeted drug delivery and other in vivo biomedical applications.

Indexed as

biomedical microrobotsdrug deliverymagnetic microrobots

Identifiers

PMID32957563
PMCPMC7569920
OpenAlexW3085309216

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.