Evidence map›Paper›PMID 32957547›Full record

ReviewInternational journal of molecular sciences2020

Isolated Lung Perfusion in the Management of Acute Respiratory Distress Syndrome.

Nathan Haywood, Matthew R Byler, Aimee Zhang, Mark E Roeser, Irving L Kron, Victor E Laubach

Open access · goldAbstract readHistorical ArticleReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Nathan HaywoodDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Matthew R BylerDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Aimee ZhangDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Mark E RoeserDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Irving L KronDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.
Victor E LaubachDepartment of Surgery, University of Virginia School of Medicine, Charlottesville, VA 22902, USA.ORCID 0000-0001-9673-5383
University of Virginia · US

Funding

Cardiovascular Surgery Training ProgramT32HL007849 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI KRON, IRVING L., LAUBACH, VICTOR E · 1998 to 2025
$7.0M
Ex vivo perfusion in a lung box for rehabilitation of donor lungsR01HL119218 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2013 to 2017
$3.3M
In Vivo Lung Perfusion for the Surgical Treatment of Acute Respiratory Distress SyndromeR01HL142110 · NHLBI · UNIVERSITY OF VIRGINIA · PI KRON, IRVING L., LAUBACH, VICTOR E · 2018 to 2021
$2.3M
The Next Step: Regadenoson mitigates ischemia reperfusion injury and is renal protective in a 48 hour porcine model of resuscitative ECMOK08HL146995 · NHLBI · UNIVERSITY OF VIRGINIA · PI ROESER, MARK · 2019 to 2023
$827k
NHLBI NIH HHS K08 HL146995NHLBI NIH HHS R01 HL119218NHLBI NIH HHS R01 HL142110NHLBI NIH HHS RO1HL119218NHLBI NIH HHS RO1HL142110NHLBI NIH HHS T32 HL007849NHLBI NIH HHS T32HL007849
6 · The paper itself

Abstract

Acute respiratory distress syndrome (ARDS) is associated with high morbidity and mortality, and current management has a dramatic impact on healthcare resource utilization. While our understanding of this disease has improved, the majority of treatment strategies remain supportive in nature and are associated with continued poor outcomes. There is a dramatic need for the development and breakthrough of new methods for the treatment of ARDS. Isolated machine lung perfusion is a promising surgical platform that has been associated with the rehabilitation of injured lungs and the induction of molecular and cellular changes in the lung, including upregulation of anti-inflammatory and regenerative pathways. Initially implemented in an ex vivo fashion to evaluate marginal donor lungs prior to transplantation, recent investigations of isolated lung perfusion have shifted in vivo and are focused on the management of ARDS. This review presents current tenants of ARDS management and isolated lung perfusion, with a focus on how ex vivo lung perfusion (EVLP) has paved the way for current investigations utilizing in vivo lung perfusion (IVLP) in the treatment of severe ARDS.

Indexed as

AnimalsHistory, 19th CenturyHistory, 20th CenturyHistory, 21st CenturyHumansInflammationLung InjuryPerfusionRespiratory Distress SyndromeTissue Donorsacute lung injuryacute respiratory distress syndromeinflammationisolated lung perfusiontherapeutics

Identifiers

PMID32957547
PMCPMC7555278
OpenAlexW3086470695

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.