Evidence map›Paper›PMID 32957412›Full record

ArticleMedicine2020

Efficacy and safety of ShenSongYangXin Capsule combined with antiarrhythmic drugs for atrial fibrillation: A protocol for systematic review and network meta-analysis.

Shuqing Shi, Jingjing Shi, Qiulei Jia, Shuai Shi, Guozhen Yuan, Yuanhui Hu

Abstract read
In one paragraph

Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Shuqing ShiCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
Jingjing ShiCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
Qiulei JiaCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
Shuai ShiCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
Guozhen YuanCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.
Yuanhui HuCardiovascular Department, Guang'anmen Hospital, China Academy of Chinese Medical Sciences.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShen-Song-Yang-Xin Capsule (SSYX), a Chinese patent medicine, combined with antiarrhythmic drugs (AADs) in the treatment of atrial fibrillation (AF) has been widely applied in clinical practice, but the results are controversial. This study aims to conduct a network meta-analysis (NMA) based on data from the randomized controlled trials (RCTs) to evaluate the efficacy and safety of SSYX combined with ADDs in the treatment of AF. METHODS AND ANALYSIS: A comprehensive systematic literature search will be conducted in Cochrane Library, PubMed, Web of Science, EMBASE, Chinese Biomedical Literature Database (SinoMed), Chinese National Knowledge Infrastructure (CNKI), and WanFang database for RCTs about SSYX combined with ADDs. The primary outcomes will be the frequency of AF attack and P-wave dispersion, and the secondary outcomes will be the symptom improvements, left atrial diameter, and adverse events. Statistical analyses will be conducted by using WinBUGS software (version 1.4.3), Stata software (version 14.0) and RevMan software (version 5.3).

resultsThe results of this NMA will provide a high-quality evidence for the efficacy of SSYX combined with ADDs in the treatment of AF, and a ranking of the therapeutic classes will also be presented.

conclusionThe protocol will provide updated evidence for the application of SSYX for AF. INTERNATIONAL PLATFORM OF REGISTERED SYSTEMATIC REVIEW AND META-ANALYSIS PROTOCOLS (INPLASY) REGISTRATION NUMBER:: The protocol of this systematic review and meta-analysis was registered on the INPLASY website (https://inplasy.com/inplasy-2020-8-0075/) and INPLASY registration number is INPLASY202080075.

Indexed as

Anti-Arrhythmia AgentsAtrial FibrillationDrugs, Chinese HerbalDrug Therapy, CombinationHumansNetwork Meta-Analysis as TopicSystematic Reviews as TopicAnti-Arrhythmia AgentsDrugs, Chinese Herbalshensongyangxin

Identifiers

PMID32957412
PMCPMC10545279

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.