Evidence map›Paper›PMID 32957374›Full record

ArticleMedicine2020

Increased expression of cystathionine beta-synthase and chemokine ligand 21 is closely associated with poor prognosis in extrahepatic cholangiocarcinoma.

Lingxiang Wang, Zhulin Yang, Zhengchun Wu, Jun He, Shu Xu, Daiqiang Li, Qiong Zou, Yuan Yuan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Lingxiang WangHunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery.
Zhulin YangHunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery.
Zhengchun WuHunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery.
Jun HeHunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery.
Shu XuHunan Provincial Key Laboratory of Hepatobiliary Disease Research, Department of General Surgery.
Daiqiang LiDepartment of Pathology, Second Xiangya Hospital.
Qiong ZouDepartment of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
Yuan YuanDepartment of Pathology, Third Xiangya Hospital, Central South University, Changsha, Hunan, PR China.
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The expression of Cystathionine beta-synthase (CBS) and Chemokine ligand 21 (CCL21) is associated with the tumorigenesis and progression of a variety of tumors, but whether alterations in their expression levels correlates with the carcinogenesis and progression of EHCC is still unknown. This study investigated the clinicopathological significance of CBS and CCL21 expression in EHCC.We investigated the correlations between the expression of CBS and CCL21 and clinicopathological characteristics in EHCC using EnVision immunohistochemistry.The expression of CBS and CCL21 was significantly higher in EHCC tumors than in nontumor tissues (P < .05 and P < .01). EHCC patients with CBS and CCL21 expression combined with lymph node metastasis, tumor cell invasion, and TNM III/IV stage had more severe conditions than those with no lymph node metastasis, distant invasion and TNM I/II stage (P < .01). Kaplan-Meier survival analysis showed that the overall survival rates for EHCC patients with negative CBS or CCL21 reaction were significantly higher than those for patients with positive CBS or CCL21 reaction((P < .01). CBS or CCL21 expression was revealed as an independent poor prognostic factor for EHCC patients by Cox multivariate analysis.The present study indicates that CBS and CCL21 expression is closely associated with the pathogenesis of clinical, pathological and biological behaviors and poor prognosis in EHCC.

Indexed as

Gene Expression Regulation, NeoplasticAdultAgedAged, 80 and overBile Duct NeoplasmsChemokine CCL21CholangiocarcinomaCystathionine beta-SynthaseFemaleHumansKaplan-Meier EstimateLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingCCL21 protein, humanChemokine CCL21Cystathionine beta-Synthase

Identifiers

PMID32957374
PMCPMC7505348
OpenAlexW3087642299

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.