Evidence map›Paper›PMID 32957029›Full record

ArticleCell calcium2020

Inositol 1,4,5-trisphosphate receptor type 3 plays a protective role in hepatocytes during hepatic ischemia-reperfusion injury.

Antônio Carlos Melo Lima Filho, Andressa França, Rodrigo M Florentino, Marcone Loiola Dos Santos, Fernanda de Oliveira Lemos, Dabny Goulart Missiaggia, Roberta Cristelli Fonseca, André Gustavo Oliveira, Meenakshisundaram Ananthanarayanan, Mateus T Guerra and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell calcium, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Antônio Carlos Melo Lima FilhoDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: carlosmlf@ufmg.br.
Andressa FrançaDepartment of Molecular Medicine, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: andressafranca@ufmg.br.
Rodrigo M FlorentinoDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: rodrigomachado@ufmg.br.
Marcone Loiola Dos SantosDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: marconemls@ufmg.br.
Fernanda de Oliveira LemosDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: folemos13@gmail.com.
Dabny Goulart MissiaggiaDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: dabnymissiaggia@gmail.com.
Roberta Cristelli FonsecaDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: rcristellif@gmail.com.
André Gustavo OliveiraDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: agoufmg@gmail.com.
Meenakshisundaram AnanthanarayananSection of Digestive Disease, Department of Internal Medicine, Yale University School of Medicine, CT, United States. Electronic address: ananth.meena@yale.edu.
Mateus T GuerraSection of Digestive Disease, Department of Internal Medicine, Yale University School of Medicine, CT, United States. Electronic address: mateus.guerra@yale.edu.
Matheus de Castro FonsecaBrazilian Biosciences National Laboratory (LNBio), Brazilian Center for Research in Energy and Materials, SP, Brazil. Electronic address: matheus.fonseca@lnbio.cnpem.br.
Paula Vieira Teixeira VidigalDepartment of Pathologic Anatomy, Medicine School of Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: pvidigal@medicina.ufmg.br.
Cristiano Xavier LimaDepartment of Surgery, Medicine School of Federal University of Minas Gerais (UFMG), MG, United States. Electronic address: cxlima@ufmg.br.
Michael H NathansonSection of Digestive Disease, Department of Internal Medicine, Yale University School of Medicine, CT, United States. Electronic address: michael.nathanson@yale.edu.
M Fatima LeiteDepartment of Biophysics and Physiology, Federal University of Minas Gerais (UFMG), MG, Brazil. Electronic address: leitemd@ufmg.br.
Universidade Federal de Minas Gerais · BRYale University · USBrazilian Center for Research in Energy and Materials · BR

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
Yale Liver CenterP30DK034989 · NIDDK · YALE UNIVERSITY · PI WAJAHAT Zafar MEHAL · 1986 to 2026
$31.1M
Translational CoreP01DK057751 · NIDDK · YALE UNIVERSITY · PI YANG, XIAOYONG · 2001 to 2020
$25.6M
Ca2+ waves in hepatocytes: Mechanisms and effectsR01DK114041 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2018 to 2022
$2.6M
Molecular regulation of cholestasis in cholangiocytesR01DK112797 · NIDDK · YALE UNIVERSITY · PI NATHANSON, MICHAEL H · 2018 to 2021
$1.9M
NCATS NIH HHS UL1 TR001863NIDDK NIH HHS P01 DK057751NIDDK NIH HHS P30 DK034989NIDDK NIH HHS R01 DK112797NIDDK NIH HHS R01 DK114041
6 · The paper itself

Abstract

Hepatic ischemia-reperfusion injury is seen in a variety of clinical conditions, including hepatic thrombosis, systemic hypotension, and liver transplantation. Calcium (Ca

Indexed as

AnimalsCalcium SignalingDisease Models, AnimalDNA DemethylationHepatocytesHumansInositol 1,4,5-Trisphosphate ReceptorsLiverMaleMice, Inbred C57BLMice, KnockoutNFATC Transcription FactorsPromoter Regions, GeneticProtective AgentsReperfusion InjuryInositol 1,4,5-Trisphosphate ReceptorsNFATC Transcription FactorsProtective AgentsCalcium signalingHepatocytesNecrosisNuclear factor of activated T-cellsTransplantation

Identifiers

PMID32957029
PMCPMC7530136
OpenAlexW3048748124

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.