ArticlePsychoneuroendocrinology2020
Serum 25-hydroxyvitamin D levels and psychological distress symptoms in patients with affective disorders during the COVID-19 pandemic.
Article in Psychoneuroendocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers, 2 of them syntheses that pooled it.
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Who cites it
38 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.
- The Acute Impact of the Early Stages of COVID-19 Pandemic in People with Pre-Existing Psychiatric Disorders: A Systematic Review.International journal of environmental research and public health · 2022Pooled it
- The role of vitamin D in the age of COVID-19: A systematic review and meta-analysis.International journal of clinical practice · 2021Pooled it
- Comparison of the role of vitamin D in normal organs and those affected by COVID-19.International journal of medical sciences · 2025Review
- Mental health problems during the COVID-19 pandemic among residents of Jimma town: a cross-sectional study.European archives of psychiatry and clinical neuroscience · 2024Article
- Physical and cognitive correlates, inflammatory levels, and treatment response in post-COVID-19 first-onset vs. recurrent depressive episodes.European archives of psychiatry and clinical neuroscience · 2024Article
- Microglial Inflammatory Responses to SARS-CoV-2 Infection: A Comprehensive Review.Cellular and molecular neurobiology · 2023Review
- The Impact of Stress from Social Isolation during the COVID-19 Pandemic on Psychiatric Disorders: An Analysis from the Scientific Literature.Brain sciences · 2023Review
- Article
- The Prevalence and Predictors of Depressive, Anxiety, and Stress Symptoms Among Tepi Town Residents During the COVID-19 Pandemic Lockdown in Ethiopia.Journal of racial and ethnic health disparities · 2023Article
- Article
- Believing processes during the COVID-19 pandemic in individuals with bipolar disorder: An exploratory study.World journal of psychiatry · 2022Article
- Being creative during lockdown: The relationship between creative potential and COVID-19-related psychological distress in narcolepsy type 1.Journal of sleep research · 2022Article
- Psychological and behavioral response on the COVID-19 pandemic in individuals with bipolar disorder: A multicenter study.Psychiatry research · 2022Article
- Mental health in individuals with severe mental disorders during the covid-19 pandemic: a longitudinal investigation.Schizophrenia (Heidelberg, Germany) · 2022Article
- A longitudinal study of post-traumatic stress, depressive, and anxiety symptoms trajectories in subjects with bipolar disorder during the COVID-19 pandemic.European psychiatry : the journal of the Association of European Psychiatrists · 2022Article
- Outdoor Activity in the Daytime, but Not the Nighttime, Predicts Better Mental Health Status During the COVID-19 Curfew in the United Arab Emirates.Frontiers in public health · 2022Article
- Psychological impact of the COVID-19 pandemic on individuals with serious mental disorders: A systematic review of the literature.World journal of psychiatry · 2021Article
- Impact of lockdown relaxation and implementation of the face-covering policy on mental health: A United Kingdom COVID-19 study.World journal of psychiatry · 2021Article
- Implications of the COVID-19 pandemic for people with bipolar disorders: A scoping review.Journal of affective disorders · 2021Article
- Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe COVID-19 pandemic has given rise to stress worldwide, especially in vulnerable people like those suffering from mental illness. This study aims to investigate the psychological distress perceived by a cohort of patients with Major Depressive Disorder (MDD) or Bipolar Disorder (BD) after a seven-week period of lockdown measures, and to analyze serum 25-hydroxyvitamin D [25(OH)D] levels as a potential predictor of distress severity.
methodsFifty-nine remitted MDD and fifty-three euthymic BD patients were enrolled. An online dedicated survey was administered to obtain lockdown-related information and to evaluate COVID-19 related distress by using the Kessler 10 Psychological Distress Scale (K10). Patients' medical records were reviewed to collect sociodemographic and clinical data, including serum 25(OH)D levels dosed in the three months preceding the outbreak. A multivariate general linear model was adopted to test the effect of factors of interest on psychological distress.
resultsIn our sample (n = 112), 29 subjects (25.9 %) reported no likelihood of psychological distress, whereas 35 (31.2 %) and 48 (42.9 %) displayed mild and moderate-to-severe likelihood of psychological distress, respectively. Low serum 25(OH)D levels (p = 0.005) and MDD diagnosis (p = 0.001) specifically predicted the severity of psychological distress. Living alone during the lockdown, a longer duration of illness, and smoking habits were more frequently detected in subjects with COVID-19 related distress.
conclusionsLow serum 25(OH)D levels and MDD diagnosis predicted an increased vulnerability to the stressful impact of the COVID-19 outbreak. Our results suggest that vitamin D may represent a biological factor mediating the psychological response to stress in individuals with affective disorders and provide further insight into tailoring intervention strategies.
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