ArticlePLoS biology2020
Encoding of social exploration by neural ensembles in the insular cortex.
Article in PLoS biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Oxytocin modulation of the insular cortex: implications for social cognition and neurodevelopmental disorders.Frontiers in neural circuits · 2026Review
- Insular input to the prelimbic cortex underlies social affective behavior in rats.bioRxiv : the preprint server for biology · 2025Article
- Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice.bioRxiv : the preprint server for biology · 2025Article
- Modulation of social valence by insular cortex activity during acute social isolation in mice.Molecular brain · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.Research square · 2025Article
- Opposite-sex pairing alters social-induced GCaMP and dopamine activity in the insula of male prairie voles.Annals of the New York Academy of Sciences · 2025Article
- A reduced ability to discriminate social from non-social touch at the circuit level may underlie social avoidance in autism.Nature communications · 2025Article
- Social Exclusion Amplifies Behavioral Responses to Physical Pain via Insular Neuromodulation.bioRxiv : the preprint server for biology · 2025Article
- A population of Insula neurons encodes for social preference only after acute social isolation in mice.Nature communications · 2024Article
- (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice.Molecular psychiatry · 2024Article
- Population coding of time-varying sounds in the nonlemniscal inferior colliculus.Journal of neurophysiology · 2024Article
- Population coding of time-varying sounds in the non-lemniscal Inferior Colliculus.bioRxiv : the preprint server for biology · 2023Article
- Social circuits and their dysfunction in autism spectrum disorder.Molecular psychiatry · 2023Review
- VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome.Cell reports · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.bioRxiv : the preprint server for biology · 2023Article
- Social affective behaviors among female rats involve the basolateral amygdala and insular cortex.PloS one · 2023Article
- Article
- Continuous high-frequency deep brain stimulation of the anterior insula modulates autism-like behavior in a valproic acid-induced rat model.Journal of translational medicine · 2022Article
- Suppressed prefrontal neuronal firing variability and impaired social representation in IRSp53-mutant mice.eLife · 2022Article
- Insular cortex corticotropin-releasing factor integrates stress signaling with social affective behavior.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The insular cortex (IC) participates in diverse complex brain functions, including social function, yet their cellular bases remain to be fully understood. Using microendoscopic calcium imaging of the agranular insular cortex (AI) in mice interacting with freely moving and restrained social targets, we identified 2 subsets of AI neurons-a larger fraction of "Social-ON" cells and a smaller fraction of "Social-OFF" cells-that change their activity in opposite directions during social exploration. Social-ON cells included those that represented social investigation independent of location and consisted of multiple subsets, each of which was preferentially active during exploration under a particular behavioral state or with a particular target of physical contact. These results uncover a previously unknown function of AI neurons that may act to monitor the ongoing status of social exploration while an animal interacts with unfamiliar conspecifics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.