Evidence map›Paper›PMID 32956023›Full record

ArticlePhysiological genomics2020

Genetic background influences the impact of KLOTHO deficiency.

Jawad S Salloum, Diane E Garsetti, Melissa B Rogers

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological genomics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jawad S SalloumDepartment of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey.
Diane E GarsettiDepartment of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey.
Melissa B RogersDepartment of Microbiology, Biochemistry, and Molecular Genetics, Rutgers - New Jersey Medical School, Newark, New Jersey.
Rutgers, The State University of New Jersey · US

Funding

BMP2 Gene Regulation in Calcific Aortic Valve DiseaseR01HL114751 · NHLBI · VANDERBILT UNIVERSITY · PI MORTLOCK, DOUGLAS P, ROGERS, MELISSA B · 2012 to 2015
$1.5M
Gene Regulatory Mechanisms that Repress BMP2 in Pathological CalcificationR01HL134947 · NHLBI · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ROGERS, MELISSA B · 2017 to 2019
$1.2M
Regulation of BMP2 in CKD Induced Calcification in the Klotho Aging ModelR56AG050762 · NIA · RBHS-NEW JERSEY MEDICAL SCHOOL · PI ROGERS, MELISSA B · 2016 to 2016
$398k
NHLBI NIH HHS R01 HL114751NHLBI NIH HHS R01HL114751NHLBI NIH HHS R01 HL134947NIA NIH HHS R56 AG050762NIA NIH HHS R56AG050762
6 · The paper itself

Abstract

Genetic background is a key but sometimes overlooked factor that profoundly impacts disease susceptibility and presentation in both humans and disease models. Here we show that deficiency of KLOTHO protein, an important renal regulator of mineral homeostasis and a cofactor for FGF23, causes different phenotypes in 129S1/SvlmJ (129) and C57BL/6J (B6) mouse strains. The 129 strain is more severely affected, with decreased longevity, decreased body weight, and increased amounts of kidney calcification compared with B6 mice. Reciprocal F1 crosses of the strains also indicate a parentage effect on the

Indexed as

Genetic BackgroundMutationPhenotypeAnimalsBody WeightFemaleFibroblast Growth Factor-23GenotypeGlucuronidaseHomeostasisHomozygoteKidney CalculiKlotho ProteinsMaleMiceMice, Inbred C57BLFGF23 protein, humanFgf23 protein, mouseFibroblast Growth Factor-23GlucuronidaseKlotho Proteins129S1/SvlmJ (129)C57Bl/6J (B6)KLOTHOparent of originrenal disease

Identifiers

PMID32956023
PMCPMC7750509
OpenAlexW3087223326

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.