Evidence map›Paper›PMID 32955723›Full record

ArticleNeurotoxicity research2021

Using the Metabolome to Understand the Mechanisms Linking Chronic Arsenic Exposure to Microglia Activation, and Learning and Memory Impairment.

Rui-Yuan Zhang, Jie-Bai Tu, Rui-Tu Ran, Wen-Xuan Zhang, Qiang Tan, Ping Tang, Tao Kuang, Shu-Qun Cheng, Cheng-Zhi Chen, Xue-Jun Jiang and 7 more

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

  1. Alzheimer's Disease Risk AllelebioRxiv : the preprint server for biology · 2026
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  9. Exposure to two-dimensional ultrathin TiJournal of nanobiotechnology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 2 institutions in 1 country.

Rui-Yuan Zhang *Department of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Jie-Bai Tu *Department of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Rui-Tu RanDepartment of Urinary Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, People's Republic of China.
Wen-Xuan ZhangDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Qiang TanDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Ping TangDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Tao KuangDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Shu-Qun ChengDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Cheng-Zhi ChenDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Xue-Jun JiangDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Chang ChenInstitute of Life Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Ting-Li HanInstitute of Life Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Ting ZhangState Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality, Chongqing Medical University, Chongqing, People's Republic of China.
Xian-Qing CaoDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China.
Bin PengDepartment of Statistics, School of Public Health and Management, Chongqing Medical University, Chongqing, People's Republic of China.
Hua ZhangInstitute of Life Sciences, Chongqing Medical University, Chongqing, People's Republic of China.
Yin-Yin XiaDepartment of Occupational and Environmental Hygiene, School of Public Health and Management, Research Center for Medicine and Social Development, Innovation Center for Social Risk Governance in Health, Chongqing Medical University, Chongqing, People's Republic of China. 100118@cqmu.edu.cn.
Chongqing Medical University · CNChongqing Public Health Medical Center · CN

Funding

Innovative Experiment Project of Chongqing Medical University CXSY201847National Natural Science Foundation of China 81602820, 81703187, 81502777Natural Science Foundation Project of Chongqing Science and Technology Commission 2015jcyjA10032, cstc2016jcyjA0223,cstc2016jcyjA0435Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (CN) 20170112Science-Technology Research Program of the Chongqing Municipal Commission of Education KJ1600204
6 · The paper itself

Abstract

The activation of microglia is a hallmark of neuroinflammation and contributes to various neurodegenerative diseases. Chronic inorganic arsenic exposure is associated with impaired cognitive ability and increased risk of neurodegeneration. The present study aimed to investigate whether chronic inorganic arsenic-induced learning and memory impairment was associated with microglial activation, and how organic (DMA

Indexed as

AnimalsArsenicCell SurvivalMaleMaze LearningMemory DisordersMetabolomeMetabolomicsMiceMice, Inbred C57BLMicrogliaArsenicArsenicMetabolomicsMicrogliaNeuroinflammationNeurotoxicity

Identifiers

PMID32955723
OpenAlexW3087628503

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.