Evidence map›Paper›PMID 32955722›Full record

ArticleNeurotoxicity research2021

Acute Traumatic Brain Injury-Induced Neuroinflammatory Response and Neurovascular Disorders in the Brain.

Duraisamy Kempuraj, Mohammad Ejaz Ahmed, Govindhasamy Pushpavathi Selvakumar, Ramasamy Thangavel, Sudhanshu P Raikwar, Smita A Zaheer, Shankar S Iyer, Raghav Govindarajan, Premkumar Nattanmai Chandrasekaran, Casey Burton and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicity research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 2 pooled it
1.9field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Duraisamy KempurajDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA. duraisamyk@health.missouri.edu.ORCID https://orcid.org/0000-0003-1148-8681
Mohammad Ejaz AhmedDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Govindhasamy Pushpavathi SelvakumarDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Ramasamy ThangavelDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Sudhanshu P RaikwarDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Smita A ZaheerDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Shankar S IyerDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Raghav GovindarajanDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Premkumar Nattanmai ChandrasekaranDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA.
Casey BurtonPhelps Health, Rolla, MO, USA.
Donald JamesPhelps Health, Rolla, MO, USA.
Asgar ZaheerDepartment of Neurology, School of Medicine, University of Missouri, 1 Hospital Drive, Columbia, MO, USA. Zaheera@health.missouri.edu.ORCID http://orcid.org/0000-0003-3344-0371
United States Department of Veterans Affairs · USUniversity of Missouri Hospital · US

Funding

Therapeutic potential of GMF suppresssion in inflammation and neurodegenerationR01AG048205 · NIA · UNIVERSITY OF MISSOURI-COLUMBIA · PI ZAHEER, ASGAR · 2015 to 2019
$1.6M
Leonard Wood Institute W911NF-14-2-0034.NIA NIH HHS R01 AG048205NIH HHS AG048205VA Research Career Scientist Award
6 · The paper itself

Abstract

Acute traumatic brain injury (TBI) leads to neuroinflammation, neurodegeneration, cognitive decline, psychological disorders, increased blood-brain barrier (BBB) permeability, and microvascular damage in the brain. Inflammatory mediators secreted from activated glial cells, neurons, and mast cells are implicated in the pathogenesis of TBI through secondary brain damage. Abnormalities or damage to the neurovascular unit is the indication of secondary injuries in the brain after TBI. However, the precise mechanisms of molecular and ultrastructural neurovascular alterations involved in the pathogenesis of acute TBI are not yet clearly understood. Moreover, currently, there are no precision-targeted effective treatment options to prevent the sequelae of TBI. In this study, mice were subjected to closed head weight-drop-induced acute TBI and evaluated neuroinflammatory and neurovascular alterations in the brain by immunofluorescence staining or quantitation by enzyme-linked immunosorbent assay (ELISA) procedure. Mast cell stabilizer drug cromolyn was administered to inhibit the neuroinflammatory response of TBI. Results indicate decreased level of pericyte marker platelet-derived growth factor receptor-beta (PDGFR-β) and BBB-associated tight junction proteins junctional adhesion molecule-A (JAM-A) and zonula occludens-1 (ZO-1) in the brains 7 days after weight-drop-induced acute TBI as compared with the brains from sham control mice indicating acute TBI-associated BBB/tight junction protein disruption. Further, the administration of cromolyn drug significantly inhibited acute TBI-associated decrease of PDGFR-β, JAM-A, and ZO-1 in the brain. These findings suggest that acute TBI causes BBB/tight junction damage and that cromolyn administration could protect this acute TBI-induced brain damage as well as its long-time consequences.

Indexed as

AnimalsBrainBrain Injuries, TraumaticCerebrovascular DisordersEncephalitisMaleMiceNeuronsBlood-brain barrierNeuroinflammationTight junction proteinsTraumatic brain injury

Identifiers

PMID32955722
PMCPMC7502806
OpenAlexW3087366098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.