Evidence map›Paper›PMID 32955617›Full record

ArticleParasitology research2020

Immunomodulatory effect of different extracts from Angiostrongylus cantonensis on airway inflammation in an allergic asthma model.

Vanessa Fey Pascoal, Aline Andrea da Cunha, Alessandra Loureiro Morassutti, Géssica Luana Antunes, Keila Abreu da Silveira, Josiane Silva Silveira, Nailê Karine Nuñez, Rodrigo Godinho de Souza, Carlos Graeff-Teixeira, Paulo Márcio Pitrez

Abstract read
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In one paragraph

Article in Parasitology research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Vanessa Fey PascoalLaboratory of Molecular Parasitology, School of Sciences, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Ave., Porto Alegre, RS, 90610-000, Brazil.
Aline Andrea da CunhaLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Alessandra Loureiro MorassuttiLaboratory of Molecular Parasitology, School of Sciences, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Ave., Porto Alegre, RS, 90610-000, Brazil. almorassutti@gmail.com.ORCID http://orcid.org/0000-0002-8142-1055
Géssica Luana AntunesLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Keila Abreu da SilveiraLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Josiane Silva SilveiraLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Nailê Karine NuñezLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Rodrigo Godinho de SouzaLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Carlos Graeff-TeixeiraLaboratory of Molecular Parasitology, School of Sciences, Pontifical Catholic University of Rio Grande do Sul, 6690 Ipiranga Ave., Porto Alegre, RS, 90610-000, Brazil.
Paulo Márcio PitrezLaboratory of Pediatric Respirology, Infant Center, School of Medicine, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre, Brazil.
Pontifícia Universidade Católica do Rio Grande do Sul · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 307005/2014-3
6 · The paper itself

Abstract

This study aimed to evaluate the effects of early-life exposure to different extracts of Angiostrongylus cantonensis (A. cantonensis) on airway inflammation in an allergic asthma model. The total soluble extract (TE) and the soluble extracts of the digestive (AcD), reproductive (AcR), and cuticle (AcC) systems of A. cantonensis were used for immunisation before ovalbumin (OVA)-sensitisation/challenge in an OVA-induced allergic asthma model. The initial hypothesis of the study was that some soluble extract of the systems (AcD, AcR, or AcC) could be more potent to the modulation of inflammation than the TE. Our data, however, shows that immunisation with the TE is more promising because it decreased the high influx of inflammatory cells on airways and promoted an increase of interferon-γ (IFN-ɣ) and interleukin-10 (IL-10) levels. Besides this, the immunisation with the TE also led to a reduction of goblet cells and mucus overproduction in the lung tissue of asthmatic mice. We believe that the extracts have a distinct capacity to modulate the immune system, due to the TE possessing a greater variability of molecules, which together leads to control of airway inflammation. In conclusion, this is the first study to reveal that the TE of A. cantonensis adult worms has a greater potential for developing a novel therapeutic for allergic asthma.

Indexed as

ImmunomodulationAngiostrongylus cantonensisAnimalsAsthmaCytokinesDisease Models, AnimalFemaleImmunizationInflammationLungMiceMice, Inbred BALB COvalbuminRespiratory MucosaCytokinesOvalbuminAngiostrongylus cantonensisAsthmaCytokinesHygiene hypothesisImmunomodulationParasites

Identifiers

PMID32955617
OpenAlexW3087448977

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.