The Fragility Index and Trial Significance.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

8 citing papers in PubMed, 4 syntheses or guidelines pooled it.

1. Robustness of placebo-controlled trials of extended-duration direct oral anticoagulant therapy for secondary venous thromboembolism prevention.Internal and emergency medicine · 2026
   Pooled it
2. How fragile the positive results of Chinese herbal medicine randomized controlled trials on irritable bowel syndrome are?BMC complementary medicine and therapies · 2024
   Pooled it
3. Assessing the robustness of COVID-19 vaccine efficacy trials: systematic review and meta-analysis, January 2023.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2023
   Pooled it
4. The Fragility of Statistically Significant Results in Randomized Clinical Trials for COVID-19.JAMA network open · 2022
   Pooled it
5. The Statistical Fragility of Lateral Extra-articular Tenodesis Research: A Systematic Review.Orthopaedic journal of sports medicine · 2024
   Article
6. Fragility of statistically significant outcomes in randomized trials comparing bariatric surgeries.International journal of obesity (2005) · 2023
   Review
7. Paediatric surgical trials, their fragility index, and why to avoid using it to evaluate results.Pediatric surgery international · 2022
   Article
8. Fragility indices for only sufficiently likely modifications.Proceedings of the National Academy of Sciences of the United States of America · 2021
   Article

Corrections and comments

• Commented on by
  The Fragility Index and Trial Significance-Reply.2020
• Comment on
  Characteristics of Contemporary Randomized Clinical Trials and Their Association With the Trial Funding Source in Invasive Cardiovascular Interventions.2020

Authors and funding

3 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as