Evidence map›Paper›PMID 32955440›Full record

ArticleeLife2020

Deciphering the regulatory genome of

William T Ireland, Suzannah M Beeler, Emanuel Flores-Bautista, Nicholas S McCarty, Tom Röschinger, Nathan M Belliveau, Michael J Sweredoski, Annie Moradian, Justin B Kinney, Rob Phillips

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 74 citations in OpenAlex.

  1. Article
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  9. Article
  10. The Environment-Dependent Regulatory Landscape of thebioRxiv : the preprint server for biology · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Targeted mutagenesis of specific genomic DNA sequences in animals for thebioRxiv : the preprint server for biology · 2024
    Article
  16. Article
  17. Article
  18. Quantitative mapping of pseudouridines in bacteria RNA.bioRxiv : the preprint server for biology · 2024
    Article
  19. Article
  20. Flexibility and sensitivity in gene regulation out of equilibrium.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

William T IrelandDepartment of Physics, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-0971-2904
Suzannah M BeelerDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-1930-4827
Emanuel Flores-BautistaDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Nicholas S McCartyDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.
Tom RöschingerDivision of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-4900-3216
Nathan M BelliveauDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-1536-1963
Michael J SweredoskiProteome Exploration Laboratory, Division of Biology and Biological Engineering, Beckman Institute, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-0878-3831
Annie MoradianProteome Exploration Laboratory, Division of Biology and Biological Engineering, Beckman Institute, California Institute of Technology, Pasadena, United States.ORCID 0000-0002-0407-2031
Justin B KinneySimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, Cold Spring Harbor, United States.ORCID 0000-0003-1897-3778
Rob PhillipsDepartment of Physics, California Institute of Technology, Pasadena, United States.ORCID 0000-0003-3082-2809
California Institute of Technology · USCold Spring Harbor Laboratory · US

Funding

PREDOCTORAL TRAINING IN BIOLOGY AND CHEMISTRYT32GM007616 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI STERNBERG, PAUL WARREN · 1985 to 2019
$22.9M
The Principles of Regulatory, Conformational and Evolutionary AdaptationR35GM118043 · NIGMS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI ROB PHILLIPS · 2016 to 2026
$7.9M
NIH Director's Pioneer Award (RMI)DP1OD000217 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI PHILLIPS, ROB · 2004 to 2008
$4.0M
Biophysical modeling of cis-regulatory complexes in transcription and splicing using massively parallel reporter assaysR35GM133777 · NIGMS · COLD SPRING HARBOR LABORATORY · PI KINNEY, JUSTIN B. · 2019 to 2023
$2.4M
Acquisition of a Q-Exactive Plus mass spectrometer.S10OD020013 · OD · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI HESS, SONJA · 2015 to 2015
$600k
Howard Hughes Medical InstituteNIGMS NIH HHS R35 GM118043NIGMS NIH HHS R35 GM133777NIGMS NIH HHS T32 GM007616NIH HHS 1S10OD02001301NIH HHS DP1 OD000217NIH HHS S10 OD020013
6 · The paper itself

Abstract

Advances in DNA sequencing have revolutionized our ability to read genomes. However, even in the most well-studied of organisms, the bacterium

Indexed as

Gene Expression Regulation, BacterialGenome, BacterialPromoter Regions, GeneticEscherichia coliSequence Analysis, DNAE. coligene expressioninformation theoryphysics of living systemsquantitative biologytranscriptional regulationtranscription factors

Identifiers

PMID32955440
PMCPMC7567609
OpenAlexW3087616106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.