Evidence map›Paper›PMID 32955433›Full record

ArticleeLife2020

Site-specific effects of neurosteroids on GABA

Yusuke Sugasawa, Wayland Wl Cheng, John R Bracamontes, Zi-Wei Chen, Lei Wang, Allison L Germann, Spencer R Pierce, Thomas C Senneff, Kathiresan Krishnan, David E Reichert and 3 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 60 citations in OpenAlex.

  1. Review
  2. GABACellular and molecular neurobiology · 2026
    Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. New directions in neurosteroid therapeutics in neuropsychiatry.Neuroscience and biobehavioral reviews · 2025
    Review
  9. Review
  10. Article
  11. Neurosteroids: a lifelong impact on brain health.Frontiers in behavioral neuroscience · 2025
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. State-dependent energetics of GABABiophysical journal · 2024
    Article
  18. Potentiation of the GABABiophysical journal · 2024
    Article
  19. Review
  20. Neurosteroid Binding and Actions on GABAJuntendo Iji zasshi = Juntendo medical journal · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 1 institution in 1 country.

Yusuke SugasawaDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0003-1607-0460
Wayland Wl ChengDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0002-9529-9820
John R BracamontesDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Zi-Wei ChenDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0001-8601-2210
Lei WangDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Allison L GermannDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Spencer R PierceDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Thomas C SenneffDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Kathiresan KrishnanDepartment of Developmental Biology, Washington University in St. Louis, St. Louis, United States.
David E ReichertTaylor Family Institute for Innovative Psychiatric Research, Washington University in St. Louis, St. Louis, United States.
Douglas F CoveyDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Gustav AkkDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.
Alex S EversDepartment of Anesthesiology, Washington University in St. Louis, St. Louis, United States.ORCID 0000-0002-0342-0575
Washington University in St. Louis · US

Funding

MOLECULAR SITES OF NEUROSTEROID BINDINGR01GM108799 · NIGMS · WASHINGTON UNIVERSITY · PI EVERS, ALEX S. · 2014 to 2022
$4.0M
SYNERGISTIC ACTIONS OF INTRAVENOUS ANESTHETICSR01GM108580 · NIGMS · WASHINGTON UNIVERSITY · PI AKK, GUSTAV · 2014 to 2021
$2.4M
Characterizing Neurosteroid Binding in the GABA(A) Receptor Using Top-Down Mass SpectrometryK08GM126336 · NIGMS · WASHINGTON UNIVERSITY · PI CHENG, WAYLAND WING-LUN · 2017 to 2019
$544k
NIGMS NIH HHS K08 GM126336NIGMS NIH HHS R01 GM108580NIGMS NIH HHS R01 GM108799NIH HHS 2R01GM108799-05NIH HHS 5K08GM126336-03NIH HHS 5R01GM108580-06
6 · The paper itself

Abstract

This study examines how site-specific binding to three identified neurosteroid-binding sites in the α

Indexed as

NeurosteroidsReceptors, GABA-AAnimalsBinding SitesCells, CulturedElectrophysiological PhenomenaMolecular Docking SimulationOocytesPregnanoloneProtein BindingXenopus laevisNeurosteroidsPregnanoloneReceptors, GABA-Adesensitizationgabaa receptorhumanmolecular biophysicsneurosteroidsphotoaffinity labelingradioligand bindingsite-directed mutagenesisstructural biology

Identifiers

PMID32955433
PMCPMC7532004
OpenAlexW3087522696

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.