SynthesisBlood transfusion = Trasfusione del sangue2020
The effect of massive transfusion protocol implementation on the survival of trauma patients: a systematic review and meta-analysis.
Synthesis in Blood transfusion = Trasfusione del sangue, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04866953 (At What Point is Blood Transfusion Futile in Trauma?), which is not on this map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
At What Point is Blood Transfusion Futile in Trauma?: A Retrospective Study of Ultra Massive Transfusion Protocol in Adult Trauma Patients Undergoing Surgery Within 24 Hours and Effects on Mortality and Clinical Outcomes
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Inhospital coagulation management and fluid replacement therapy in patients with multiple and/or severe injuries - a systematic review and clinical practice guideline update.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2025Pooled it
- Transfusion strategies in bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.Intensive care medicine · 2021Guideline
- Article
- [Interpretation of the 2025Zhonghua shao shang yu chuang mian xiu fu za zhi · 2026Article
- Best practices on blood and blood products for a prehospital hemorrhage protocol: consensus from the 2025 Canadian prehospital transfusion summit.Scandinavian journal of trauma, resuscitation and emergency medicine · 2026Article
- Cognitive Biases in Early Trauma Transfusions: Lessons From Three Rare Cases of Acute Hemolytic Reaction.Clinical case reports · 2026Article
- Good neurological outcome after traumatic cardiopulmonary arrest with extreme acidosis (pH 6.62): a case report.Resuscitation plus · 2026Article
- Hemostatic resuscitation in patients with trauma-induced coagulopathy: a narrative review.Acute and critical care · 2026Article
- Key strategies in trauma anesthesia for severe hemorrhage: a narrative review.Korean journal of anesthesiology · 2026Review
- Review
- Improving the Compliance of Massive Hemorrhage Protocols Through Education Is Associated with Patient Survival.Journal of clinical medicine · 2025Article
- Analysis of Massive Transfusion Protocol Utilization in Trauma Across Sociodemographic Groups.Medicina (Kaunas, Lithuania) · 2025Article
- Transfusion in trauma: empiric or guided therapy?Research and practice in thrombosis and haemostasis · 2025Article
- A Case of Atraumatic Splenic Rupture Due to T-Cell/Histiocyte-Rich Large B-Cell Lymphoma and a Potential Role for Massive Transfusion Protocol.Case reports in surgery · 2025Article
- Platelet-Lymphocyte and Neutrophil-Lymphocyte Ratio for Prediction of Hospital Outcomes in Patients with Abdominal Trauma.BioMed research international · 2022Article
- Sustainability in pediatric hospitals: An exploration at the intersection of quality improvement and implementation science.Frontiers in health services · 2022Article
- If not now, when? The value of the MTP in managing massive bleeding.Blood transfusion = Trasfusione del sangue · 2020Article
- A Selection of Trauma Scores Might Not Correlate with Coagulation Factor Activity following Multiple Injuries: A Retrospective Observational Study from a Level 1 Trauma Center.BioMed research international · 2020Observational
- Identification of Predictive Factors for Massive Transfusion Activation in Trauma Patients: A Systematic Review and Meta-analysis.Journal of emergencies, trauma, and shockArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMassive transfusion protocol (MTP) has been widely adopted for the care of bleeding trauma patients but its actual effectiveness is unclear. An earlier meta-analysis on the implementation of MTP for injured patients from 1990 to 2013 reported that only 2 out of 8 studies showed statistical improvement in survival. This study aimed to conduct an updated systematic review and meta-analysis to evaluate the effect of implementing an MTP on the mortality of trauma patients. MATERIALS AND
methodsMEDLINE, PubMed, Cochrane Library and Google scholar databases were systematically searched for relevant studies published from 1
resultsFourteen studies met inclusion criteria, analysing outcomes from 3,201 trauma patients. There was a wide range of outcomes, patient populations, and process indicators utilised by the different authors. MTP significantly reduced the overall mortality for trauma patients (OR 0.71 [0.56-0.90]). No significant reduction was seen in either the 24-hour mortality (OR 0.81 [0.57-1.14]) or the 30-day mortality (OR 0.73 [0.46-1.16]). However, when mortality timing was unspecified, mortality was statistically reduced (OR 0.69 [0.55-0.86]). DISCUSSION: The present study found a significant reduction in mortality following MTP implementation and thus it should be recommended to all institutions managing acutely injured patients. To better identify which elements of an MTP contribute to this effect, we encourage the use of standard nomenclature, indicators, protocols and patient populations in all future MTP studies.
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