ArticleACR open rheumatology2020
A Detailed Analysis of the Association between Urate Deposition and Erosions and Osteophytes in Gout.
Article in ACR open rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 15 citations in OpenAlex.
- Distinct Characteristics of Patients with Gout and an Underweight or Normal Body Mass Index: A Single-Center Retrospective Cross-Sectional Study.Life (Basel, Switzerland) · 2025Article
- [Gout : From the diagnosis to guideline-based treatment].Zeitschrift fur Gerontologie und Geriatrie · 2025Article
- Unconventional Imaging Methods in Psoriatic Arthritis.Current rheumatology reports · 2025Review
- Anti-inflammatory Properties of Tongfeng Li'an Granules in an Acute Gouty Arthritis Rat Model.ACS omega · 2024Article
- Serum ionized magnesium acts as an independent protective factor against bone erosion in patients with gouty arthritis: a cross-sectional study.Frontiers in endocrinology · 2024Article
- Detailed analysis of the association between urate deposition and bone erosion in gout: a dual-energy computed tomography study.Frontiers in endocrinology · 2023Article
- Dual-energy CT assessment of rapid monosodium urate depletion and bone erosion remodelling during pegloticase plus methotrexate co-therapy.Rheumatology (Oxford, England) · 2022Article
- Development of a radiographic scoring system for new bone formation in gout.Arthritis research & therapy · 2021Article
Corrections and comments
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Authors and funding
14 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo characterize in detail the structural bone changes associated with the deposition of monosodium urate crystals in the first metatarsophalangeal (MTP1) joint in patients with tophaceous gout.
methodsTwenty patients with tophaceous gout and involvement of the MTP1 joint received both dual-energy computed tomography (DECT) of the feet for the detection of tophi and high-resolution peripheral quantitative computed tomography (HR-pQCT) of the feet for the detection of bone erosions and osteophytes. Demographic and clinical data were collected. Tophi in DECT and erosions and osteophytes in HR-pQCT were overlayed to define their anatomical relation. In addition, the feet of 20 sex- and age-matched healthy controls were scanned to define the normal architecture of the MTP1 joint.
resultsPatients with gout had an increased number and extent of bone erosions and osteophytes compared with their healthy counterparts (erosions: 5 [0-17] vs 1 [1-2], 45.32 mm
conclusionGout patients show increased changes in their bone microarchitecture. The extent of uric acid deposition is positively correlated with the extent of bone loss at the MTP1 joint, highlighting the strong cohesion of inflammation and erosive changes.
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Registered trials
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