ArticleSchizophrenia bulletin2021
Deconstructing Negative Symptoms in Individuals at Clinical High-Risk for Psychosis: Evidence for Volitional and Diminished Emotionality Subgroups That Predict Clinical Presentation and Functional Outcome.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 32 citations in OpenAlex.
- The effect of monetary versus point-based rewards on effort-cost decision making in individuals at clinical high risk for psychosis.Schizophrenia research · 2026Trial
- Exercise Intervention in Individuals at Clinical High Risk for Psychosis: Benefits to Fitness, Symptoms, Hippocampal Volumes, and Functional Connectivity.Schizophrenia bulletin · 2022Trial
- Right hippocampal volume and attenuated psychotic symptoms distinguish subgroups of youth with common patterns of temporoparietal effective connectivity.Brain structure & function · 2026Article
- Salience network segregation and symptom profiles in psychosis risk subgroups among youth and early adults.Schizophrenia (Heidelberg, Germany) · 2025Article
- Motivation and Pleasure Domain Links to Social Function in College Students: A Network Analysis.PsyCh journal · 2025Article
- A generalized reward processing deficit pathway to negative symptoms across diagnostic boundaries.Psychological medicine · 2025Article
- Self-concept and Narrative Identity in Youth at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2024Article
- Anhedonia in adolescents at transdiagnostic familial risk for severe mental illness: Clustering by symptoms and mechanisms of association with behavior.Journal of affective disorders · 2024Article
- Longitudinal evaluation on negative symptoms in young people at Ultra-High Risk (UHR) of psychosis: results from a 2-year follow-up study in a real-world care setting.European archives of psychiatry and clinical neuroscience · 2023Article
- Reinforcement learning profiles and negative symptoms across chronic and clinical high-risk phases of psychotic illness.European archives of psychiatry and clinical neuroscience · 2023Article
- Clinical high risk for psychosis syndrome is associated with reduced neural responding to unpleasant images.Journal of psychopathology and clinical science · 2023Article
- Speech characteristics yield important clues about motor function: Speech variability in individuals at clinical high-risk for psychosis.Schizophrenia (Heidelberg, Germany) · 2023Article
- Genuine and non-genuine smiles in individuals meeting criteria for a clinical high-risk syndrome.Early intervention in psychiatry · 2022Article
- Clinical, Brain, and Multilevel Clustering in Early Psychosis and Affective Stages.JAMA psychiatry · 2022Article
- History of trauma is a critical treatment target for individuals at clinical high-risk for psychosis.Frontiers in psychiatry · 2022Article
- The Latent Structure of Negative Symptoms in the General Population in Adolescence and Emerging Adulthood.Schizophrenia bulletin open · 2022Article
- Reciprocal Social Behavior and Related Social Outcomes in Individuals at Clinical High Risk for Psychosis.Psychiatry research · 2021Article
- The COVID-19 Pandemic Introduces Diagnostic and Treatment Planning Complexity for Individuals at Clinical High Risk for Psychosis.Schizophrenia bulletin · 2021Article
- Secondary Sources of Negative Symptoms in Those Meeting Criteria for a Clinical High-Risk Syndrome.Biological psychiatry global open science · 2021Article
- Abnormal Gesture Perception and Clinical High-Risk for Psychosis.Schizophrenia bulletin · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Negative symptoms are characteristic of schizophrenia and closely linked to numerous outcomes. A body of work has sought to identify homogenous negative symptom subgroups-a strategy that can promote mechanistic understanding and precision medicine. However, our knowledge of negative symptom subgroups among individuals at clinical high-risk (CHR) for psychosis is limited. Here, we investigated distinct negative symptom profiles in a large CHR sample (N = 244) using a cluster analysis approach. Subgroups were compared on external validators that are (1) commonly observed in the schizophrenia literature and/or (2) may be particularly relevant for CHR individuals, informing early prevention and prediction. We observed 4 distinct negative symptom subgroups, including individuals with (1) lower symptom severity, (2) deficits in emotion, (3) impairments in volition, and (4) global elevations. Analyses of external validators suggested a pattern in which individuals with global impairments and volitional deficits exhibited more clinical pathology. Furthermore, the Volition group endorsed more disorganized, anxious, and depressive symptoms and impairments in functioning compared to the Emotion group. These data suggest there are unique negative symptom profiles in CHR individuals, converging with studies in schizophrenia indicating motivational deficits may be central to this symptom dimension. Furthermore, observed differences in CHR relevant external validators may help to inform early identification and treatment efforts.
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