Evidence map›Paper›PMID 32954922›Full record

ArticleGut microbes2020

A novel probiotic therapeutic in a murine model of

Rita D Shelby, Grace E Janzow, Lauren Mashburn-Warren, Jeffrey Galley, Natalie Tengberg, Jason Navarro, Miriam Conces, Michael T Bailey, Steven D Goodman, Gail E Besner

Open access · goldAbstract read
In one paragraph

Article in Gut microbes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.5field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 32 citations in OpenAlex.

  1. Trial
  2. Virulence · 2026
    Article
  3. Dietary iron attenuatesVirulence · 2025
    Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Next-Generation Probiotic Therapy to Protect the Intestines From Injury.Frontiers in cellular and infection microbiology · 2022
    Review
  14. Nutrients · 2021
    Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Rita D ShelbyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatric Surgery, Nationwide Children's Hospital , Columbus, OH, USA.
Grace E JanzowCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatric Surgery, Nationwide Children's Hospital , Columbus, OH, USA.
Lauren Mashburn-WarrenCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.
Jeffrey GalleyCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatric Surgery, Nationwide Children's Hospital , Columbus, OH, USA.
Natalie TengbergCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatric Surgery, Nationwide Children's Hospital , Columbus, OH, USA.
Jason NavarroDepartment of Pathology, Nationwide Children's Hospital , Columbus, OH, USA.
Miriam ConcesDepartment of Pathology, Nationwide Children's Hospital , Columbus, OH, USA.
Michael T BaileyCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.
Steven D GoodmanCenter for Microbial Pathogenesis, The Research Institute at Nationwide Children's Hospital , Columbus, OH, USA.
Gail E BesnerCenter for Perinatal Research, The Research Institute at Nationwide Children's Hospital, Department of Pediatric Surgery, Nationwide Children's Hospital , Columbus, OH, USA.
Nationwide Children's Hospital · US

Funding

Tunable Native Probiotic Formulations for the Treatment of NEC.R01GM123482 · NIGMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI BAILEY, MICHAEL T, BESNER, GAIL E · 2017 to 2020
$1.8M
NIGMS NIH HHS R01 GM123482
6 · The paper itself

Abstract

For prophylactic therapy, mice received an oral antibiotic cocktail followed by clindamycin injection, followed by probiotic administration (planktonic In the A single dose of

Indexed as

Disease Models, AnimalAnimalsAnti-Bacterial AgentsBiofilmsClostridioides difficileClostridium InfectionsColitisFemaleHumansLimosilactobacillus reuteriMaleMiceMice, Inbred C57BLProbioticsAnti-Bacterial AgentsbiofilmC. difficilelactobacillus reuteriprobioticsprophylactic treatmenttherapeutic treatment

Identifiers

PMID32954922
PMCPMC7524353
OpenAlexW3087396330

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.