ArticleMicrobial biotechnology2021
Membrane disruption of Fusarium oxysporum f. sp. niveum induced by myriocin from Bacillus amyloliquefaciens LZN01.
Article in Microbial biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Biocontrol potential of endophytic Sphingobium xenophagum J-1 against Fusarium oxysporum causing root rot in Paris polyphylla var. yunnanensis.Scientific reports · 2026Article
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- Soil microbiome bacteria protect plants against filamentous fungal infections via intercellular contacts.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Production-optimized fermentation of antifungal compounds by bacillus velezensis LZN01 and transcriptome analysis.Microbial biotechnology · 2024Article
- Sini San ameliorates lipid metabolism in hyperprolactinemia rat with liver-depression.Current research in food science · 2024Article
- Review
- The Extracellular Lipopeptides and Volatile Organic Compounds ofJournal of fungi (Basel, Switzerland) · 2023Article
- Cyclic Lipopeptides ofJournal of fungi (Basel, Switzerland) · 2023Article
- Suppression of Fusarium Wilt in Watermelon byJournal of fungi (Basel, Switzerland) · 2023Article
- Citric Acid in Rice Root Exudates Enhanced the Colonization and Plant Growth-Promoting Ability of Bacillus altitudinis LZP02.Microbiology spectrum · 2022Article
- Identification of Lipopeptide Iturin A Produced byFoods (Basel, Switzerland) · 2022Article
- Metabolites derived from fungi and bacteria suppress in vitro growth of Gnomoniopsis smithogilvyi, a major threat to the global chestnut industry.Metabolomics : Official journal of the Metabolomic Society · 2022Article
- AntimicrobialAntibiotics (Basel, Switzerland) · 2022Review
- Defence response in plants and animals against a common fungal pathogenCurrent research in microbial sciences · 2022Review
- Comprehensive transcriptomic and proteomic analyses identify intracellular targets for myriocin to induce Fusarium oxysporum f. sp. niveum cell death.Microbial cell factories · 2021Article
- Membrane disruption of Fusarium oxysporum f. sp. niveum induced by myriocin from Bacillus amyloliquefaciens LZN01.Microbial biotechnology · 2021Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Myriocin, which is produced by Bacillus amyloliquefaciens LZN01, can inhibit the growth of Fusarium oxysporum f. sp. niveum (Fon). In the present study, the antifungal mechanism of myriocin against Fon was investigated with a focus on the effects of myriocin on the cell membrane. Myriocin decreased the membrane fluidity and destroyed the membrane integrity of Fon. Significant microscopic morphological changes, including conidial shrinkage, the appearance of larger vacuoles and inhomogeneity of electron density, were observed in myriocin-treated cells. A membrane-targeted mechanism of action was also supported by transcriptomic and proteomic analyses; a total of 560 common differentially expressed genes (DEGs) and 285 common differentially expressed proteins (DEPs) were identified. The DEGs were further verified by using RT-qPCR. The combined analysis between the transcriptome and proteome revealed that the expression of some membrane-related genes and proteins, mainly those related to sphingolipid metabolism, glycerophospholipid metabolism, steroid biosynthesis, ABC transporters and protein processing in the endoplasmic reticulum, was disordered. Myriocin affected the serine palmitoyl transferase (SPT) activity as evidenced through molecular docking. Our results indicate that myriocin has significant antifungal activity owing to its ability to induce membrane damage in Fon.
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