Evidence map›Paper›PMID 32954465›Full record

ArticleJournal of gastrointestinal cancer2021

Lymph Node Ratio Is an Independent Prognostic Factor for Patients with Siewert Type II Adenocarcinoma of Esophagogastric Junction: Results from a 10-Year Follow-up Study.

Yuling Zhang, Ditian Liu, De Zeng, Chunfa Chen

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Article in Journal of gastrointestinal cancer, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Yuling ZhangDepartment of Medical Information, Shantou University Medical College Cancer Hospital, Shantou, China.
Ditian LiuDepartment of Thoracic Surgery, Shantou University Medical College Cancer Hospital, Shantou, China.
De ZengDepartment of Medical Oncology, Shantou University Medical College Cancer Hospital, Shantou, China. dezeng@stu.edu.cn.ORCID http://orcid.org/0000-0002-1128-485X
Chunfa ChenThe Breast Centre, Shantou University Medical College Cancer Hospital, Shantou, China. chenchunfa@stu.edu.cn.

Funding

Natural Science Foundation of Guangdong Province 2018A030313562Science and Technology Project of Shantou(CN) 170828211930352Science and Technology Project of Shantou(CN) 190816095262235Science and Technology Project of Shantou(CN) 190819145262877Science and Technology Special Fund of Guangdong Province Shantou Government 2019-132Special Fund for Science and Technology Innovation Strategy of Guangdong Province Shantou Government 2018-49Youth Scientific Research Fund of Cancer Hospital affiliated to Shantou University Medical College 2020A003
6 · The paper itself

Abstract

purposeEmerging evidences suggest that lymph node ratio (LNR), the number of metastatic lymph node (LN) to the total number of dissected lymph nodes (NDLN), may predict survival in multiple types of solid tumor. However, the prognostic role of LNR in adenocarcinoma of the esophagogastric junction (AEG) remains uninvestigated. The present study is intended to determine the prognostic value of LNR in the patients with Siewert type II AEG.

methodsA total of 342 patients with Siewert type II AEG who underwent R0 resection were enrolled in this study. The optimal cutoff of LNR was stratified into tertiles using X-tile software. The log-rank test was used to evaluate the survival differences, and multivariate Cox regression analyses were performed to determine the independent prognostic variables.

resultsThe optimal cutoff of LNR were classified as LNR = 0, LNR between 0.01 and 0.40, and LNR > 0.41. Patients with high LNR had a shorter 5- and 10-year disease-specific survival (DSS) rate (8.5%, 1.4%) compared with those with moderate LNR (20.4%, 4.9%) and low LNR (58.0%, 27.5%) (P < 0.001). Multivariate Cox regression analysis indicated that LNR was an independent factor for DSS after adjusting for confounding variables (P < 0.05). Furthermore, after stratification by NDLN between NDLN < 15 group and NDLN ≥ 15 group, the LNR remained a significant predictor for DSS (P < 0.05).

conclusionsLNR is an independent predictor for DSS in patients with Siewert type II AEG regardless of NDLN. Patients with higher LNR have significantly shorter DSS.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overEsophageal NeoplasmsEsophagogastric JunctionFemaleFollow-Up StudiesHumansLymph Node RatioMaleMiddle AgedNeoplasm StagingPrognosisStomach NeoplasmsAdenocarcinoma of the esophagogastric junctionLymph node ratioNumber of dissected lymph nodesPrognosis

Identifiers

PMID32954465

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.