Evidence map›Paper›PMID 32954412›Full record

Trial reportSleep2021

The evening light environment in hospitals can be designed to produce less disruptive effects on the circadian system and improve sleep.

Daniel Vethe, Jan Scott, Morten Engstrøm, Øyvind Salvesen, Trond Sand, Alexander Olsen, Gunnar Morken, Hanne S Heglum, Kaia Kjørstad, Patrick M Faaland and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors.

Daniel VetheDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Jan ScottDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Morten EngstrømDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Øyvind SalvesenUnit of Applied Clinical Research, Norwegian University of Science and Technology, Trondheim, Norway.
Trond SandDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Alexander OlsenDepartment of Psychology, Norwegian University of Science and Technology, Trondheim, Norway.
Gunnar MorkenDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Hanne S HeglumDepartment of Neuromedicine and Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Kaia KjørstadDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Patrick M FaalandDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Cecilie L VestergaardDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Knut LangsrudDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.
Håvard KallestadDepartment of Mental Health, Norwegian University of Science and Technology, Trondheim, Norway.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

STUDY

objectivesBlue-depleted lighting reduces the disruptive effects of evening artificial light on the circadian system in laboratory experiments, but this has not yet been shown in naturalistic settings. The aim of the current study was to test the effects of residing in an evening blue-depleted light environment on melatonin levels, sleep, neurocognitive arousal, sleepiness, and potential side effects.

methodsThe study was undertaken in a new psychiatric hospital unit where dynamic light sources were installed. All light sources in all rooms were blue-depleted in one half of the unit between 06:30 pm and 07:00 am (melanopic lux range: 7-21, melanopic equivalent daylight illuminance [M-EDI] range: 6-19, photopic lux range: 55-124), whereas the other had standard lighting (melanopic lux range: 30-70, M-EDI range: 27-63, photopic lux range: 64-136), but was otherwise identical. A total of 12 healthy adults resided for 5 days in each light environment (LE) in a randomized cross-over trial.

resultsMelatonin levels were less suppressed in the blue-depleted LE (15%) compared with the normal LE (45%; p = 0.011). Dim light melatonin onset was phase-advanced more (1:20 h) after residing in the blue-depleted LE than after the normal LE (0:46 h; p = 0.008). Total sleep time was 8.1 min longer (p = 0.032), rapid eye movement sleep 13.9 min longer (p < 0.001), and neurocognitive arousal was lower (p = 0.042) in the blue-depleted LE. There were no significant differences in subjective sleepiness (p = 0.16) or side effects (p = 0.09).

conclusionsIt is possible to create an evening LE that has an impact on the circadian system and sleep without serious side effects. This demonstrates the feasibility and potential benefits of designing buildings or hospital units according to chronobiological principles and provide a basis for studies in both nonclinical and clinical populations.

Indexed as

Circadian RhythmLightMelatoninSleepAdultHospitalsHumansWakefulnessMelatoninarousalcircadian rhythmshospitalslightingsleep

Identifiers

PMID32954412
PMCPMC7953207

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.