ArticleCerebral cortex (New York, N.Y. : 1991)2021
Effects of Amygdala Lesions on Object-Based Versus Action-Based Learning in Macaques.
Article in Cerebral cortex (New York, N.Y. : 1991), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed.
- Perceptual response patterns in rhesus macaque attentional set shifting are associated with inflexible behavior.Cognitive, affective & behavioral neuroscience · 2026Article
- Contribution of amygdala to dynamic model arbitration under uncertainty.Nature communications · 2025Article
- Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.Nature communications · 2024Article
- Computational Mechanisms Underlying Motivation to Earn Symbolic Reinforcers.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Motor System-Dependent Effects of Amygdala and Ventral Striatum Lesions on Explore-Exploit Behaviors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Dissociable Contributions of Basolateral Amygdala and Ventrolateral Orbitofrontal Cortex to Flexible Learning Under Uncertainty.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- The motivational role of the ventral striatum and amygdala in learning from gains and losses.Behavioral neuroscience · 2023Article
- Mechanisms of adjustments to different types of uncertainty in the reward environment across mice and monkeys.Cognitive, affective & behavioral neuroscience · 2023Article
- Multiple routes of communication within the amygdala-mPFC network: A comparative approach in humans and macaques.Current research in neurobiology · 2023Review
- Prefrontal cortex interactions with the amygdala in primates.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Review
- Zunyimycin C enhances immunity and improves cognitive impairment and its mechanism.Frontiers in cellular and infection microbiology · 2022Article
- Organization of parietoprefrontal and temporoprefrontal networks in the macaque.Journal of neurophysiology · 2021Article
- Toward a holistic view of value and social processing in the amygdala: Insights from primate behavioral neurophysiology.Behavioural brain research · 2021Review
- Functions of primate amygdala neurons in economic decisions and social decision simulation.Behavioural brain research · 2021Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
The neural systems that underlie reinforcement learning (RL) allow animals to adapt to changes in their environment. In the present study, we examined the hypothesis that the amygdala would have a preferential role in learning the values of visual objects. We compared a group of monkeys (Macaca mulatta) with amygdala lesions to a group of unoperated controls on a two-armed bandit reversal learning task. The task had two conditions. In the What condition, the animals had to learn to select a visual object, independent of its location. And in the Where condition, the animals had to learn to saccade to a location, independent of the object at the location. In both conditions choice-outcome mappings reversed in the middle of the block. We found that monkeys with amygdala lesions had learning deficits in both conditions. Monkeys with amygdala lesions did not have deficits in learning to reverse choice-outcome mappings. Rather, amygdala lesions caused the monkeys to become overly sensitive to negative feedback which impaired their ability to consistently select the more highly valued action or object. These results imply that the amygdala is generally necessary for RL.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.