ArticleSleep2021
Sleep health, diseases, and pain syndromes: findings from an electronic health record biobank.
Article in Sleep, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social jetlag and obesity: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2024Pooled it
- Sharing approaches in predictive genomics across animals, plants and humans.Nature genetics · 2026Review
- Sleep Disturbances and Acne: A Comprehensive Review.Dermatology practical & conceptual · 2025Review
- Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index with disease outcomes and their interaction in a clinical biobank.Sleep health · 2025Article
- Phenome-wide associations of sleep characteristics in the Human Phenotype Project.Nature medicine · 2025Article
- Clinical and genetic associations for night eating syndrome in a patient biobank.Journal of eating disorders · 2024Article
- Anxiety and depression are associated with heightened risk of incident deep vein thrombosis: Mediation through stress-related neural mechanisms.American journal of hematology · 2024Article
- Sleep and home parenteral nutrition in adults: A narrative review.Nutrition in clinical practice : official publication of the American Society for Parenteral and Enteral Nutrition · 2024Review
- Genetic and functional analysis of Raynaud's syndrome implicates loci in vasculature and immunity.Cell genomics · 2024Article
- Home parenteral nutrition, sleep patterns, and depressive symptoms: Secondary analysis of cross-sectional data.JPEN. Journal of parenteral and enteral nutrition · 2024Article
- Sleep-wake changes and incident depressive symptoms in midlife women.Scientific reports · 2024Article
- The Importance of Sleep in Overcoming Childhood Obesity and Reshaping Epigenetics.Biomedicines · 2024Review
- Associations of a multidimensional polygenic sleep health score and a sleep lifestyle index on health outcomes and their interaction in a clinical biobank.medRxiv : the preprint server for health sciences · 2024Article
- The causal relationship between sleep characteristics and multi-site pain perception: a two-sample Mendelian randomization study.Frontiers in neuroscience · 2024Article
- Patient Characteristics Associated With Reactions to Mrgprx2-Activating Drugs in an Electronic Health Record-Linked Biobank.The journal of allergy and clinical immunology. In practice · 2023Observational
- Infusion timing and sleep habits of adults receiving home parenteral and enteral nutrition: A patient-oriented survey study.JPEN. Journal of parenteral and enteral nutrition · 2023Article
- Sleep patterns of patients receiving home parenteral nutrition: A home-based observational study.JPEN. Journal of parenteral and enteral nutrition · 2022Observational
- Genetic evidence for a potential causal relationship between insomnia symptoms and suicidal behavior: a Mendelian randomization study.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2022Article
- How Accurately Can We Recall the Timing of Food Intake? A Comparison of Food Times from Recall-Based Survey Questions and Daily Food Records.Current developments in nutrition · 2022Article
- Interaction of obesity polygenic score with lifestyle risk factors in an electronic health record biobank.BMC medicine · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
STUDY
objectivesImplementation of electronic health record biobanks has facilitated linkage between clinical and questionnaire data and enabled assessments of relationships between sleep health and diseases in phenome-wide association studies (PheWAS). In the Mass General Brigham Biobank, a large health system-based study, we aimed to systematically catalog associations between time in bed, sleep timing, and weekly variability with clinical phenotypes derived from ICD-9/10 codes.
methodsSelf-reported habitual bed and wake times were used to derive variables: short (<7 hours) and long (≥9 hours) time in bed, sleep midpoint, social jetlag, and sleep debt. Logistic regression and Cox proportional hazards models were used to test cross-sectional and prospective associations, respectively, adjusted for age, gender, race/ethnicity, and employment status and further adjusted for body mass index.
resultsIn cross-sectional analysis (n = 34,651), sleep variable associations were most notable for circulatory system, mental disorders, and endocrine/metabolic phenotypes. We observed the strongest associations for short time in bed with obesity, for long time in bed and sleep midpoint with major depressive disorder, for social jetlag with hypercholesterolemia, and for sleep debt with acne. In prospective analysis (n = 24,065), we observed short time in bed associations with higher incidence of acute pain and later sleep midpoint and higher sleep debt and social jetlag associations with higher incidence of major depressive disorder.
conclusionsOur analysis reinforced that sleep health is a multidimensional construct, corroborated robust known findings from traditional cohort studies, and supported the application of PheWAS as a promising tool for advancing sleep research. Considering the exploratory nature of PheWAS, careful interrogation of novel findings is imperative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.