ReviewEndocrinology2020
Circadian Rhythms and the Gastrointestinal Tract: Relationship to Metabolism and Gut Hormones.
Review in Endocrinology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 53 citations in OpenAlex.
- Sleep restriction induces histoarchitectural and cellular remodeling in the rat distal colon: a peripheral consequence of circadian disruption.Biochemistry and biophysics reports · 2026Article
- Sleep, Stress, Circadian Rhythm, and Diet in Pediatric Disorders of Gut-Brain Interaction: A Narrative Review.Nutrients · 2026Review
- Early growth restriction disrupts mice intestinal clock and homeostasis without being prevented by lactoferrin.Pediatric research · 2026Article
- The Gastro-Circadian Metabolic Axis: A Comprehensive Framework for Chronotherapy in Gastroenterology.Cureus · 2026Review
- A One Health Decalogue for Breastfeeding: Microbiota-Targeted Strategies for Infant Gastrointestinal and Neurodevelopmental Health.Nutrients · 2026Review
- Expression of gastrointestinal clock genes and associated hormones levels in hibernating and non-hibernating Daurian ground squirrels.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2026Article
- Circadian Rhythms in Gastroenterology: The Biological Clock's Impact on Gut Health.Gastroenterology · 2025Review
- Diurnal function and expression of aquaporins in the mouse kidney.American journal of physiology. Renal physiology · 2025Article
- Chrononutrition: Potential, Challenges, and Application in Managing Obesity.International journal of molecular sciences · 2025Review
- Clinical Chronobiology: Circadian Rhythms in Health and Disease.Seminars in neurology · 2025Review
- The time is now: accounting for time-of-day effects to improve reproducibility and translation of metabolism research.Nature metabolism · 2025Review
- Chitosan lactate improves repeated closed head injury-generated motor and neurological dysfunctions in mice by impacting microbiota gut-brain axis.Metabolic brain disease · 2025Article
- Chronobiology of Cancers in the Liver and Gut.Cancers · 2024Review
- Biological Rhythms, Chrono-Nutrition, and Gut Microbiota: Epigenomics Insights for Precision Nutrition and Metabolic Health.Biomolecules · 2024Review
- Genes of cancer-related fatigue: a scoping review.Frontiers in oncology · 2024Article
- The REV-ERB Nuclear Receptors: Timekeepers for the Core Clock Period and Metabolism.Endocrinology · 2023Review
- A New Role for Endocrine Cells in the Intestinal Crypt.Cellular and molecular gastroenterology and hepatology · 2023Article
- Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents.Frontiers in nutrition · 2023Review
- Circadian Clock Desynchronization and Insulin Resistance.International journal of environmental research and public health · 2022Review
- Disrupted and Elevated Circadian Secretion of Glucagon-Like Peptide-1 in a Murine Model of Type 2 Diabetes.Endocrinology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Circadian rhythms are 24-hour biological rhythms within organisms that have developed over evolutionary time due to predefined environmental changes, mainly the light-dark cycle. Interestingly, metabolic tissues, which are largely responsible for establishing diurnal metabolic homeostasis, have been found to express cell-autonomous clocks that are entrained by food intake. Disruption of the circadian system, as seen in individuals who conduct shift work, confers significant risk for the development of metabolic diseases such as type 2 diabetes and obesity. The gastrointestinal (GI) tract is the first point of contact for ingested nutrients and is thus an essential organ system for metabolic control. This review will focus on the circadian function of the GI tract with a particular emphasis on its role in metabolism through regulation of gut hormone release. First, the circadian molecular clock as well as the organization of the mammalian circadian system is introduced. Next, a brief overview of the structure of the gut as well as the circadian regulation of key functions important in establishing metabolic homeostasis is discussed. Particularly, the focus of the review is centered around secretion of gut hormones; however, other functions of the gut such as barrier integrity and intestinal immunity, as well as digestion and absorption, all of which have relevance to metabolic control will be considered. Finally, we provide insight into the effects of circadian disruption on GI function and discuss chronotherapeutic intervention strategies for mitigating associated metabolic dysfunction.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.