Evidence map›Paper›PMID 32954347›Full record

ArticleBrain communications2020

Stable high frequency background EEG activity distinguishes epileptic from healthy brain regions.

Annika Minthe, Wibke G Janzarik, Daniel Lachner-Piza, Peter Reinacher, Andreas Schulze-Bonhage, Matthias Dümpelmann, Julia Jacobs

Abstract read
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Annika MintheDepartment of Neuropediatrics and Muscular Diseases, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Wibke G JanzarikDepartment of Neuropediatrics and Muscular Diseases, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Daniel Lachner-PizaDepartment of Neurosurgery, Epilepsy Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.ORCID 0000-0001-6137-3394
Peter ReinacherDivision of Stereotactic and Functional Neurosurgery, Department of Neurosurgery, Clinic for Neurosurgery, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Andreas Schulze-BonhageDepartment of Neurosurgery, Epilepsy Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Matthias DümpelmannDepartment of Neurosurgery, Epilepsy Center, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.
Julia JacobsDepartment of Neuropediatrics and Muscular Diseases, Medical Center - University of Freiburg, Faculty of Medicine, University of Freiburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

High-frequency oscillations are markers of epileptic tissue. Recently, different patterns of EEG background activity were described from which high-frequency oscillations occur: high-frequency oscillations with continuously oscillating background were found to be primarily physiological, those from quiet background were linked to epileptic tissue. It is unclear, whether these interactions remain stable over several days and during different sleep-wake stages. High-frequency oscillation patterns (oscillatory vs. quiet background) were analysed in 23 patients implanted with depth and subdural grid electrodes. Pattern scoring was performed on every channel in 10 s intervals in three separate day- and night-time EEG segments. An entropy value, measuring variability of patterns per channel, was calculated. A low entropy value indicated a stable occurrence of the same pattern in one channel, whereas a high value indicated pattern instability. Differences in pattern distribution and entropy were analysed for 143 280 10 s intervals with allocated patterns from inside and outside the seizure onset zone, different electrode types and brain regions. We found a strong association between high-frequency oscillations out of quiet background activity, and channels of the seizure onset zone (35.2% inside versus 9.7% outside the seizure onset zone,

Indexed as

epilepsyepilepsy surgeryhigh-frequency oscillationsintracranial EEGrefractory epilepsy

Identifiers

PMID32954347
PMCPMC7475693

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.