Evidence map›Paper›PMID 32954337›Full record

ArticleBrain communications2020

Neural correlates of polygenic risk score for autism spectrum disorders in general population.

Budhachandra Khundrakpam, Uku Vainik, Jinnan Gong, Noor Al-Sharif, Neha Bhutani, Gregory Kiar, Yashar Zeighami, Matthias Kirschner, Cheng Luo, Alain Dagher and 1 more

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 4 countries.

Budhachandra KhundrakpamMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Uku VainikMontreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Jinnan GongMontreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Noor Al-SharifMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Neha BhutaniMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Gregory KiarMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Yashar ZeighamiMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Matthias KirschnerMontreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Cheng LuoClinical Hospital of Chengdu Brain Science Institute, MOE Ley Lab for Neuroinformation, Center for Information in Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan 611731, China.ORCID 0000-0003-0524-5886
Alain DagherMontreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0002-0945-5779
Alan EvansMcGill Centre for Integrative Neuroscience, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada.
Montreal Neurological Institute and Hospital · CAUniversity of Electronic Science and Technology of China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder is a highly prevalent and highly heritable neurodevelopmental condition, but studies have mostly taken traditional categorical diagnosis approach (yes/no for autism spectrum disorder). In contrast, an emerging notion suggests a continuum model of autism spectrum disorder with a normal distribution of autistic tendencies in the general population, where a full diagnosis is at the severe tail of the distribution. We set out to investigate such a viewpoint by investigating the interaction of polygenic risk scores for autism spectrum disorder and Age

Indexed as

autism spectrum disorderscortical thicknessgeneticspolygenic risk scorestructural connectivity

Identifiers

PMID32954337
PMCPMC7475696
OpenAlexW3041707696

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.