ReviewBrain communications2020
Microelectrode recordings in human epilepsy: a case for clinical translation.
Review in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Trends and hotspots of stereoelectroencephalogram from 2002 to 2023: a bibliometric analysis.Frontiers in neurology · 2024Pooled it
- Microelectrode Implantation in Human Insula: Technical Challenges and Recording Insights.Brain sciences · 2025Article
- Article
- Electrode Arrays for Detecting and Modulating Deep Brain Neural Information in Primates: A Review.Cyborg and bionic systems (Washington, D.C.) · 2025Review
- Single unit-derived connectivity networks in tuberous sclerosis complex reveal propensity for network hypersynchrony driven by tuber-tuber interactions.Scientific reports · 2024Article
- Direct visualization of microwires in hybrid depth electrodes using high-resolution photon-counting CT.Epilepsia open · 2024Article
- Simultaneous invasive and non-invasive recordings in humans: A novel Rosetta stone for deciphering brain activity.Journal of neuroscience methods · 2024Review
- Flexible, scalable, high channel count stereo-electrode for recording in the human brain.Nature communications · 2024Article
- Networks through the lens of high-frequency oscillations.Frontiers in network physiology · 2024Review
- Modified Neuropixels probes for recording human neurophysiology in the operating room.Nature protocols · 2023Review
- Quantitative approaches to guide epilepsy surgery from intracranial EEG.Brain : a journal of neurology · 2023Article
- Electrochemical and electrophysiological considerations for clinical high channel count neural interfaces.MRS bulletin · 2023Article
- Seizure detection with reduced electroencephalogram channels: research trends and outlook.Royal Society open science · 2023Review
- A novel method for dynamically altering the surface area of intracranial EEG electrodes.Journal of neural engineering · 2023Article
- Neural adaptation and fractional dynamics as a window to underlying neural excitability.PLoS computational biology · 2023Article
- Effect of intracranial electrical stimulation on dynamic functional connectivity in medically refractory epilepsy.Frontiers in human neuroscience · 2023Article
- Towards network-guided neuromodulation for epilepsy.Brain : a journal of neurology · 2022Review
- Previous, current, and future stereotactic EEG techniques for localising epileptic foci.Expert review of medical devices · 2022Review
- Drug-resistant focal epilepsy in children is associated with increased modal controllability of the whole brain and epileptogenic regions.Communications biology · 2022Article
- Full-bandwidth electrophysiology of seizures and epileptiform activity enabled by flexible graphene microtransistor depth neural probes.Nature nanotechnology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With their 'all-or-none' action potential responses, single neurons (or units) are accepted as the basic computational unit of the brain. There is extensive animal literature to support the mechanistic importance of studying neuronal firing as a way to understand neuronal microcircuits and brain function. Although most studies have emphasized physiology, there is increasing recognition that studying single units provides novel insight into system-level mechanisms of disease. Microelectrode recordings are becoming more common in humans, paralleling the increasing use of intracranial electroencephalography recordings in the context of presurgical evaluation in focal epilepsy. In addition to single-unit data, microelectrode recordings also record local field potentials and high-frequency oscillations, some of which may be different to that recorded by clinical macroelectrodes. However, microelectrodes are being used almost exclusively in research contexts and there are currently no indications for incorporating microelectrode recordings into routine clinical care. In this review, we summarize the lessons learnt from 65 years of microelectrode recordings in human epilepsy patients. We cover the electrode constructs that can be utilized, principles of how to record and process microelectrode data and insights into ictal dynamics, interictal dynamics and cognition. We end with a critique on the possibilities of incorporating single-unit recordings into clinical care, with a focus on potential clinical indications, each with their specific evidence base and challenges.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.