Evidence map›Paper›PMID 32954300›Full record

ArticleBrain communications2020

Loss of MINAR2 impairs motor function and causes Parkinson's disease-like symptoms in mice.

Rachel Xi-Yeen Ho, Razie Amraei, Kyle Oliver Corcino De La Cena, Evan G Sutherland, Farzad Mortazavi, Thor Stein, Vipul Chitalia, Nader Rahimi

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Emerging complexities of the mouse as a model for human hearing loss.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  6. Mutations inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Rachel Xi-Yeen HoDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.ORCID 0000-0002-8346-2328
Razie AmraeiDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.
Kyle Oliver Corcino De La CenaDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.
Evan G SutherlandDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.ORCID 0000-0001-5737-9451
Farzad MortazaviDepartment of Anatomy and Neurobiology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.
Thor SteinDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.ORCID 0000-0001-6954-4477
Vipul ChitaliaDepartment of Medicine, Boston University School of Medicine, Boston, MA, USA.
Nader RahimiDepartment of Pathology, School of Medicine, Boston University Medical Campus, Boston, MA 02118, USA.ORCID 0000-0002-6745-1725
Boston University · US

Funding

Thrombotic complication of uremia: role of prothrombotic uremic solutesR01HL132325 · NHLBI · BOSTON MEDICAL CENTER · PI CHITALIA, VIPUL C · 2016 to 2019
$1.7M
NHLBI NIH HHS R01 HL132325
6 · The paper itself

Abstract

Parkinson's disease is the second most common human neurodegenerative disease. Motor control impairment represents a key clinical hallmark and primary clinical symptom of the disease, which is further characterized by the progressive loss of dopaminergic neurons in the substantia nigra pars compacta and the accumulation of α-synuclein aggregations. We have identified major intrinsically disordered NOTCH2-associated receptor 2 encoded by

Indexed as

KIAA1024KIAA1024LMINAR1MINAR2Parkinson’s disease

Identifiers

PMID32954300
PMCPMC7425422
OpenAlexW3018434642

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.