Evidence map›Paper›PMID 32954285›Full record

ArticleBrain communications2020

Association of neuroinflammation with episodic memory: a [

Noora Lindgren, Jouni Tuisku, Eero Vuoksimaa, Semi Helin, Mira Karrasch, Päivi Marjamäki, Jaakko Kaprio, Juha O Rinne

Open access · goldAbstract read
In one paragraph

Article in Brain communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Noora LindgrenTurku PET Centre, University of Turku, Turku 20521, Finland.ORCID 0000-0003-1054-2607
Jouni TuiskuTurku PET Centre, University of Turku, Turku 20521, Finland.
Eero VuoksimaaInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Semi HelinTurku PET Centre, University of Turku, Turku 20521, Finland.
Mira KarraschDepartment of Psychology, Åbo Akademi University, Turku 20500, Finland.
Päivi MarjamäkiTurku PET Centre, University of Turku, Turku 20521, Finland.
Jaakko KaprioInstitute for Molecular Medicine Finland, HiLIFE, University of Helsinki, Helsinki 00014, Finland.
Juha O RinneTurku PET Centre, University of Turku, Turku 20521, Finland.
University of Turku · FIUniversity of Helsinki · FIÅbo Akademi University · FI

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease is associated with chronic response of innate immune system, referred as neuroinflammation. PET radioligands binding to the 18 kDa translocator protein are potential biomarkers of neuroinflammation. Translocator protein PET studies in mild cognitive impairment and Alzheimer's disease have indicated controversial results, possibly reflecting interindividual variation and heterogeneity of study populations. We controlled for genetic and environmental effects by studying twin pairs discordant for episodic memory performance. Episodic memory impairment is a well-known cognitive hallmark of early Alzheimer's disease process. Eleven same-sex twin pairs (four monozygotic pairs, six female pairs, age 72-77 years) underwent [

Indexed as

Alzheimer’s diseasemild cognitive impairmentneuroinflammationPET imagingtwins

Identifiers

PMID32954285
PMCPMC7425350
OpenAlexW3010593309

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.