ArticleKidney international reports2020
Creatinine Fluctuations Forecast Cross-Harvest Kidney Function Decline Among Sugarcane Workers in Guatemala.
Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Kidney health among adolescents living in a high-risk region for CKDu.BMC nephrology · 2026Article
- G20 Country Burden of High BMI-Related Liver Cancer: Trends from 1990 to 2021 and Projections to 2050.Journal of epidemiology and global health · 2026Article
- Evaluating the effects of heat strain and air pollution on kidney health.Environment international · 2026Article
- Longitudinal Estimated GFR Trajectories Among Workers at High Risk for CKD of Unknown Etiology.Kidney international reports · 2025Article
- Understanding Changes in Serum Creatinine During Work in Heat.Kidney international reports · 2025Article
- Airborne particulate matter exposure in male sugarcane workers at risk for chronic kidney disease in Guatemala.Annals of work exposures and health · 2025Article
- The work-recovery cycle of kidney strain and inflammation in sugarcane workers following repeat heat exposure at work and at home.European journal of applied physiology · 2025Article
- Longitudinal Renal Function Degradation Among Florida Agricultural Workers.Journal of occupational and environmental medicine · 2024Article
- Environmental and Social Factors Associated with High Chronic Kidney Disease Mortality Rates in Municipalities of Guatemala: An Ecological Study of Municipal-Level Mortality Data.International journal of environmental research and public health · 2023Article
- Prevalence of kidney disease of unknown etiology in agricultural workers, Guatemala.Revista panamericana de salud publica = Pan American journal of public health · 2023Article
- Point-of-care biomarkers for prediction of kidney function trajectory among sugarcane cutters: a comparative test accuracy study.BMJ open · 2022Article
- Preclinical Safety Assessment of Chemically Cross-Linked Modified Mandua Starch: Acute and Sub-Acute Oral Toxicity Studies in Swiss Albino Mice.ACS omega · 2022Article
- Sugarcane Workweek Study: Mechanisms Underlying Daily Changes in Creatinine.Kidney international reports · 2021Article
- Article
- Sugarcane Workweek Study: Risk Factors for Daily Changes in Creatinine.Kidney international reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundChronic kidney disease of unknown origin (CKDu) is an epidemic that disproportionately affects young agriculture workers in hot regions. It has been hypothesized that repeated acute kidney injury (AKI) may play a role in the development of disease.
methodsLatent class mixed models were used to identify groups of Guatemalan sugarcane harvesters based on their daily changes in creatinine over 6 consecutive days in 2018. Exponential smoothing state space models were used to forecast end-of-season creatinine between the identified groups. Percent change in estimated glomerular filtration rate (eGFR) across the harvest was compared between groups.
resultsTwenty-nine percent (n = 30) of the 103 workers experienced repeated severe fluctuations in creatinine across shift. The model with multiplicative error, multiplicative trend, and multiplicative seasonality was able to accurately forecast end-of-season creatinine in the severe group (mean percentage error [MPE]: -4.7%). eGFR of workers in the severe group on average decreased 20% across season compared to 11% decline for those in the moderate group (95% confidence interval for difference: -17% to 0%).
conclusionsDaily fluctuations in creatinine can be used to forecast end-of-season creatinine in sugarcane harvesters. Workers who experience repeat severe daily fluctuations in creatinine, on average, experience a greater reduction in kidney function across the season.
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