Evidence map›Paper›PMID 32954074›Full record

ArticleKidney international reports2020

Etiologies, Clinical Features, and Outcome of Oxalate Nephropathy.

Benoit Buysschaert, Selda Aydin, Johann Morelle, Valentine Gillion, Michel Jadoul, Nathalie Demoulin

Open access · goldAbstract read
In one paragraph

Article in Kidney international reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 63 citations in OpenAlex.

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  10. Hyperoxaluria: Diagnosis and Treatment.The Urologic clinics of North America · 2025
    Review
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  15. Accumulation of heavy metals in the mycelium of Abortiporus biennis and their effect on oxalate oxidase activity.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Benoit BuysschaertDivision of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Selda AydinInstitut de Recherche Expérimentale et Clinique, UCLouvain, Brussels, Belgium.
Johann MorelleDivision of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Valentine GillionDivision of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Michel JadoulDivision of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Nathalie DemoulinDivision of Nephrology, Cliniques universitaires Saint-Luc, Brussels, Belgium.
Cliniques Universitaires Saint-Luc · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOxalate nephropathy is a potentially underestimated cause of kidney failure characterized by massive deposition of calcium oxalate crystals in the renal parenchyma. The prevalence and modes of presentation of this entity are ill-defined.

methodsHere we report on the largest consecutive series of cases of adult oxalate nephropathy diagnosed on native kidney biopsies from January 2010 to December 2018 in the UCLouvain Kidney Disease Network.

resultsWe screened 2265 native kidney biopsies and identified 22 cases (1%) of oxalate nephropathy. Patients had a mean age at diagnosis of 61 years (±20) and presented either with acute on chronic kidney disease (CKD) (62%) or with acute kidney injury (AKI) (38%). Mean serum creatinine at biopsy was 8.0 ± 4.5 mg/dl. Kidney biopsies showed abundant calcium oxalate crystal deposits, associated with acute interstitial nephritis and tubular necrosis, and variable degrees of interstitial fibrosis and tubular atrophy. Chronic pancreatitis and gastric bypass were the most common causes of oxalate nephropathy (48%). During a mean follow-up of 29 months, half of the patients (52%) progressed to kidney failure, all within the month following diagnosis. Higher serum creatinine level at presentation and interstitial fibrosis and tubular atrophy score were associated with progression to kidney failure.

conclusionOxalate nephropathy is the cause of kidney disease in 1% of consecutive native kidney biopsies and typically presents as acute on CKD or AKI. The prognosis of the disease is poor, with a high rate of kidney failure within the first month after the diagnosis.

Indexed as

chronic pancreatitisfat malabsorptiongastric bypasshyperoxaluriasteatorrhea

Identifiers

PMID32954074
PMCPMC7486173
OpenAlexW3039170356

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.