Evidence map›Paper›PMID 32953927›Full record

ArticleMolecular therapy. Methods & clinical development2020

Direct Functional Protein Delivery with a Peptide into Neonatal and Adult Mammalian Inner Ear

Kun Zhang, Xiaoting Cheng, Liping Zhao, Mingqian Huang, Yong Tao, Hongbo Zhang, Jessica M Rosenholm, Min Zhuang, Zheng-Yi Chen, Bing Chen and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells.Chemical engineering journal (Lausanne, Switzerland : 1996) · 2024
    Article
  2. Review
  3. Extracellular vesicles for developing targeted hearing loss therapy.Journal of controlled release : official journal of the Controlled Release Society · 2024
    Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 3 countries.

Kun ZhangENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Xiaoting ChengENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Liping ZhaoENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Mingqian HuangDepartment of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA.
Yong TaoDepartment of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, China.
Hongbo ZhangPharmaceutical Sciences Laboratory and Turku Bioscience Center, Åbo Akademi University, 20520 Turku, Finland.
Jessica M RosenholmPharmaceutical Sciences Laboratory and Turku Bioscience Center, Åbo Akademi University, 20520 Turku, Finland.
Min ZhuangSchool of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China.
Zheng-Yi ChenDepartment of Otolaryngology-Head and Neck Surgery, Harvard Medical School, Boston, MA 02115, USA.
Bing ChenENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Yilai ShuENT Institute and Otorhinolaryngology Department, Eye and ENT Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai 200031, China.
Eye & ENT Hospital of Fudan University · CNÅbo Akademi University · FIFudan University · CNHarvard University · USShanghai Ninth People's Hospital · CNShanghaiTech University · CN

Funding

Hair Cell DevelopmentR01DC006908 · NIDCD · MASSACHUSETTS GENERAL HOSPITAL · PI CHEN, ZHENG-YI · 2005 to 2015
$2.7M
Efficient in Vivo RNP-based Gene Editing in the Sensory Organ Inner Ear Using Bioreducible Lipid NanoparticlesUG3TR002636 · NCATS · MASSACHUSETTS EYE AND EAR INFIRMARY · PI CHEN, ZHENG-YI, LIU, DAVID R · 2018 to 2020
$2.4M
Hair Cell DevelopmentR56DC006908 · NIDCD · MASSACHUSETTS EYE AND EAR INFIRMARY · PI CHEN, ZHENG-YI · 2018 to 2018
$340k
NCATS NIH HHS UG3 TR002636NIDCD NIH HHS R01 DC006908NIDCD NIH HHS R56 DC006908
6 · The paper itself

Abstract

The aim of this study was to study an antimicrobial peptide (AMP), aurein 1.2, which substantially increased protein delivery directly into multiple mammalian inner-ear cell types

Indexed as

antibacterial peptidesaurein 1.2inner earsupercharged GFPtargeted delivery

Identifiers

PMID32953927
PMCPMC7477795
OpenAlexW3039657144

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.