Evidence map›Paper›PMID 32953756›Full record

ArticleAnnals of translational medicine2020

Ventricular arrhythmias in patients with functional mitral regurgitation and implantable cardiac devices: implications of mitral valve repair with Mitraclip

Tomás Benito-González, Xavier Freixa, Cosmo Godino, Maurizio Taramasso, Rodrigo Estévez-Loureiro, Daniel Hernandez-Vaquero, Ana Serrador, Luis Nombela-Franco, David Grande-Prada, Ignacio Cruz-González and 8 more

Abstract read
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Tomás Benito-GonzálezDepartment of Cardiology, University Hospital of León, León, Spain.
Xavier FreixaDepartment of Cardiology, Cardiovascular Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Cosmo GodinoDepartment of Cardiology, San Raffaele Hospital, Milan, Italy.
Maurizio TaramassoHeart Valve Clinic, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Rodrigo Estévez-LoureiroDepartment of Cardiology, University Hospital of León, León, Spain.
Daniel Hernandez-VaqueroHeart Área, Hospital Universitario Central de Asturias, Faculty of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Ana SerradorDepartment of Cardiology. Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), University Clinic Hospital of Valladolid, Valladolid, Spain.
Luis Nombela-FrancoCardiovascular Institute, Hospital Clínico San Carlos (IdISSC), Madrid, Spain.
David Grande-PradaDepartment of Cardiology, University Hospital Virgen de la Victoria, Málaga, Spain.
Ignacio Cruz-GonzálezDepartment of Cardiology, University Hospital Clínico de Salamanca, Biomedical Research Networking Center on Cardiovascular Diseases (CIBERCV), Biomedical Research Institute of Salamanca (IBSAL), Salamanca, Spain.
Rodolfo San AntonioDepartment of Cardiology, Cardiovascular Clinic Institute, Hospital Clinic, University of Barcelona, Barcelona, Spain.
Michele GalassoDepartment of Cardiology, San Raffaele Hospital, Milan, Italy.
Mara GavazzoniHeart Valve Clinic, University Hospital of Zurich, University of Zurich, Zurich, Switzerland.
Carmen GarroteDepartment of Cardiology, University Hospital of León, León, Spain.
Antonio Portolés-HernándezDepartment of Cardiology, University Hospital Puerta de Hierro, Majadahonda, Madrid, Spain.
Pablo AvanzasHeart Área, Hospital Universitario Central de Asturias, Faculty of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.
Felipe Fernández-VázquezDepartment of Cardiology, University Hospital of León, León, Spain.
Isaac PascualHeart Área, Hospital Universitario Central de Asturias, Faculty of Medicine, University of Oviedo, Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Oviedo, Spain.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLimited information has been reported regarding the impact of percutaneous mitral valve repair (PMVR) on ventricular arrhythmic (VA) burden. The aim of this study was to address the incidence of VA and appropriate antitachycardia implantable cardiac defibrillator (ICD) therapies before and after PMVR.

methodsWe retrospectively analyzed all consecutive patients with heart failure with reduce left ventricular ejection fraction (LVEF), functional mitral regurgitation (FMR) grade 3+ or 4+ and an active ICD or cardiac resynchronizer who underwent PMVR in any of the eleven recruiting centers. Only patients with complete available device VA monitoring from one-year before to one year after PMVR were included. Baseline clinical and echocardiographic characteristics were collected before PMVR and at 12-months follow-up.

resultsNinety-three patients (68.2±10.9 years old, male 88.2%) were enrolled. PMVR was successfully performed in all patients and device success at discharge was 91.4%. At 12-month follow-up, we observed a significant reduction in mitral regurgitation severity, NT-proBNP and prevalence of severe pulmonary hypertension and severe kidney disease. Patients also referred a significant improvement in NYHA functional class and showed a non-significant trend to reserve left ventricular remodeling. After PMVR a significant decrease in the incidence of non-sustained ventricular tachycardia (VT) (5.0±17.8

conclusionsPMVR was related to a reduction in arrhythmic burden and ICD therapies in our cohort.

Indexed as

functional mitral regurgitation (FMR)heart failure with reduced ejection fractionimplantable cardiac devicesMitraClip®ventricular arrhythmias

Identifiers

PMID32953756
PMCPMC7475388

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.