Evidence map›Paper›PMID 32953726›Full record

ArticleAnnals of translational medicine2020

Intensity-modulated particle beam radiation therapy in the management of olfactory neuroblastoma.

Weixu Hu, Jiyi Hu, Jing Gao, Jing Yang, Xianxin Qiu, Lin Kong, Jiade J Lu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of translational medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Weixu HuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Jiyi HuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Jing GaoDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Jing YangDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Xianxin QiuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Lin KongShanghai Engineering Research Center of Proton and Heavy Ion Radiation Therapy, Shanghai, China.
Jiade J LuDepartment of Radiation Oncology, Shanghai Proton and Heavy Ion Center, Shanghai, China.
Center for High Pressure Science & Technology Advanced Research · CNFudan University Shanghai Cancer Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo report the clinical experience and short-term efficacy in the management of olfactory neuroblastoma (ONB).

methodsWe performed a retrospective analysis of 12 ONB patients treated with particle beam radiation therapy (PBRT) between 12/2015 and 5/2019 at the Shanghai Proton and Heavy Ion Center. Four (33.3%) patients presented with Kadish B ONB, and 8 (66.7%) presented with Kadish C or D disease. Eleven patients received proton radiotherapy (PRT) followed by a carbon ion radiotherapy (CIRT) boost, one patient received CIRT only. The 2-year survival rates were calculated using the Kaplan-Meier method. Acute and late adverse events were summarized and scored according to the CTCAE (version 4.03).

resultsWith a median follow-up of 17.5 (range, 2.53-49.9) months, all patients but 1 were alive. Eight patients were alive without evidence of disease, and 2 additional patients achieved partial response and remained alive with residual disease. One patient died of toxicity associated with salvage chemotherapy for distant metastasis and local failure. Another patient developed distant metastasis only and was alive at the time of the last follow-up. The 2-year OS, PFS, LRPFS, and DMFS rates were 83.3%, 75.8%, 87.5%, and 79.5%, respectively. No acute or late toxicities of ≥ grade 3 was observed.

conclusionsIntensity modulated PBRT of ONB is well tolerated. While longer follow-up is needed, early outcomes suggested that PBRT is safe and effective for the treatment of ONB with minimal adverse events.

Indexed as

carbon ion radiationEsthesioneuroblastomaolfactory neuroblastoma (ONB)proton beam radiationradiotherapy

Identifiers

PMID32953726
PMCPMC7475427
OpenAlexW3047014122

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.