ArticleGland surgery2020
Predictive factors of lateral lymph node metastasis in conventional papillary thyroid carcinoma.
Article in Gland surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Risk factors of skip lateral cervical lymph node metastasis in papillary thyroid carcinoma: a systematic review and meta-analysis.Endocrine · 2022Pooled it
- Therapeutic Strategy in Low-Risk Papillary Thyroid Carcinoma - Long-Term Results of the First Single-Center Prospective Non-Randomized Trial Between 2011 and 2015.Frontiers in endocrinology · 2021Trial
- Clinical significance of multimodal ultrasound features in predicting cervical lymph node metastasis in papillary thyroid carcinoma with cystic change.Quantitative imaging in medicine and surgery · 2026Article
- Correction: Multi-gene co-mutations of BRAF with TERT, PIK3CA, or TP53 are powerful predictors of central lymph node metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2026Article
- Association of gravidity, parity, and abortion history with nodal metastasis in women with papillary thyroid carcinoma: a retrospective cohort study.Frontiers in endocrinology · 2026Article
- A nomogram based on the 3-gene signature and clinical characteristics for predicting lymph node metastasis in papillary thyroid cancer.Cancer biomarkers : section A of Disease markers · 2025Article
- Multi-gene co-mutations ofFrontiers in endocrinology · 2025Article
- Impact of thyroid carcinoma invasion of recurrent laryngeal nerve on cervical lymph node metastasis.Endocrine · 2024Article
- Prediction of bilateral thyroid carcinoma and lateral cervical lymph node metastasis in PTC patients with suspicious thyroid nodules.Endocrine · 2024Article
- Predictive Factors Affecting the Development of Lateral Lymph Node Metastasis in Papillary Thyroid Cancer.Sisli Etfal Hastanesi tip bulteni · 2023Article
- Article
- The Prognostic Implication of the BRAF V600E Mutation in Papillary Thyroid Cancer in a Chinese Population.International journal of endocrinology · 2022Article
- Fasting serum glucose and lymph node metastasis in non-diabetic PTC patients: a 10-Year multicenter retrospective study.Journal of Cancer · 2022Article
- Nomograms for the prediction of lateral lymph node metastasis in papillary thyroid carcinoma: Stratification by size.Frontiers in oncology · 2022Article
- Risk factors and prediction model of level II lymph node metastasis in papillary thyroid carcinoma.Frontiers in oncology · 2022Article
- Related factor analysis for predicting large-volume central cervical lymph node metastasis in papillary thyroid carcinoma.Frontiers in endocrinology · 2022Article
- Male Gender Is Associated with Lymph Node Metastasis but Not with Recurrence in Papillary Thyroid Carcinoma.International journal of endocrinology · 2022Article
- Construction and validation of a nomogram for predicting cervical lymph node metastasis in classic papillary thyroid carcinoma.Journal of endocrinological investigation · 2021Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLymph node metastasis (LNM) has been a significant predictor for local recurrence and distant metastasis in papillary thyroid carcinoma (PTC). However, the clinical predictors for conventional papillary thyroid carcinoma (CPTC) with lateral lymph node metastasis (LLNM) have yet to be established. Our work aimed to effectively identify the risk factors of LLNM in CPTC, helping surgeons to devise better individualized therapy strategies.
methodsWe retrospectively analyzed 652 patients who were diagnosed with CPTC in the Department of General Surgery at Guangdong Provincial People's Hospital between October 2015 and June 2019. Univariate and multivariate logistic regression was used to analyze the correlation between clinicopathological characteristics and the LLNM of CPTC.
resultsThe incidence of LLNM in CPTC was 29.75% (194 of 652 patients). Univariate analysis found that LLNM was significantly associated with gender, age, number of central lymph nodes (CLNs), primary tumor location, multifocality, maximum tumor diameter, and BRAF V600E mutation. Independent risk factors for LLNM were multifocality (P=0.017, OR =4.325, 95% CI: 1.298-14.408), maximum tumor diameter (P<0.001, OR =4.076, 95% CI: 1.945-8.540), primary tumor location (P=0.037, OR =2.127, 95% CI: 1.046-4.328), number of CLNs (P<0.001, OR =8.604, 95% CI: 3.630-20.390), and BRAF V600E mutation (P=0.001, OR =3.913, 95% CI: 1.803-8.496) by multivariate analysis.
conclusionsLLNM in CPTC was related to the large volume of central lymph node metastasis (CLNM), tumor located in the upper lobe, multifocality, tumor diameter >2 cm, and BRAF V600E mutation-negative, which should be considered when examining patients with suspected metastasis in the lateral compartment.
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