Evidence map›Paper›PMID 32953505›Full record

ArticleTranslational lung cancer research2020

Prognostic value of log odds of positive lymph nodes in node-positive lung squamous cell carcinoma patients after surgery: a SEER population-based study.

Yue Yu, Peng Zhang, Renqi Yao, Junnan Wang, Pei Wang, Xiaofei Xue, Jian Xiao, Zhinong Wang

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
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Article in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yue YuDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Peng ZhangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Renqi YaoTrauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing, China.
Junnan WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Pei WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiaofei XueDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Jian XiaoDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Zhinong WangDepartment of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, Shanghai, China.
Shanghai Changzheng Hospital · CNSecond Military Medical University · CNChanghai Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLog odds of positive lymph nodes (LODDS) is a novel and promising ratio-based lymph node (LN) staging system in many malignancies. This study aimed to evaluate the prognostic value of LODDS, and comprehensively compare the prognostic predictive performance of LODDS with the American Joint Committee on Cancer (AJCC) N classification, number of positive lymph node (NPLN), and lymph node ratio (LNR) among node-positive lung squamous cell carcinoma (SCC) patients after surgery.

methodsWe identified 2,561 patients with N1/N2 stage SCC diagnosed between 2004 and 2014 from the Surveillance, Epidemiology, and End Results (SEER) database. X-tile analysis was used to calculate the optimal cut-off value for each staging system. Univariable and Multivariable Cox regression analyses were used to assess the association of cancer-specific survival (CSS), and overall survival (OS) with N, NPLN, LNR, and LODDS, separately, and integrally. Moreover, linear trend χ

resultsThe optimal cut-off values for NPLN, LNR, and LODDS were 3, 0.28, and -0.37, respectively. N, NPLN, LNR, and LODDS were identified as independent prognostic predictors for CSS and OS in patients with SCC when each of them was incorporated into multivariable Cox model separately. Additionally, LODDS had the higher linear trend χ

conclusionsLODDS showed better predictive performance than N, NPLN, and LNR among patients with node-positive SCC after surgery. A combination of LODDS and the current AJCC TNM classification has the potential for becoming a better staging method to more precisely predicting prognosis.

Indexed as

Log odds of positive lymph nodes (LODDS)non-small cell lung cancer (NSCLC)prognosissquamous cell carcinoma (SCC)Surveillance, Epidemiology, and End Results (SEER)

Identifiers

PMID32953505
PMCPMC7481584
OpenAlexW3044548432

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.