ArticleTranslational lung cancer research2020
Cancer-associated changes of emotional brain network in non-nervous system metastatic non-small cell lung cancer patients: a structural connectomic diffusion tensor imaging study.
Article in Translational lung cancer research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 19 citations in OpenAlex.
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- Altered resting-state functional connectivity in lung cancer patients with comorbid depressive symptoms.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Association of regional specificity of blood-brain barrier permeability with pathological subtypes in cerebral white matter of patients with non-brain metastatic lung cancer.Frontiers in oncology · 2026Article
- Directional interactions from non-small cell lung cancer to brain glucose metabolism revealed by total-body PET imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- Uncovering brain functional connectivity disruption patterns of lung cancer-related pain.Brain imaging and behavior · 2024Article
- Effectiveness of the treatment of depression associated with cancer and neuroimaging changes in depression-related brain regions in patients treated with the mediator-deuterium acupuncture method.Open life sciences · 2023Article
- Altered temporal-parietal morphological similarity networks in non-small cell lung cancer patients following chemotherapy: an MRI preliminary study.Brain imaging and behavior · 2022Article
- A Comparative Analysis of White Matter Structural Networks on SCLC Patients After Chemotherapy.Brain topography · 2022Article
- Topological Abnormalities of Pallido-Thalamo-Cortical Circuit in Functional Brain Network of Patients With Nonchemotherapy With Non-small Cell Lung Cancer.Frontiers in neurology · 2022Article
- Altered Brain Functional Network Topology in Lung Cancer Patients After Chemotherapy.Frontiers in neurology · 2021Article
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11 authors at 2 institutions in 1 country.
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Abstract
backgroundEmotional distress frequently occur in cancer patients following diagnosis. Previous neuroimaging studies have demonstrated that depression and anxiety are associated with functional and structural brain abnormalities. However, little is known about the cancer-associated changes of emotional brain network in non-small cell lung cancer (NSCLC) patients. The aim of this study was to assess the topological features of brain structural network and emotions in non-nervous system metastatic NSCLC patients prior to chemotherapy.
methodsTwenty-four treatment-naïve patients with non-nervous system metastatic NSCLC and 25 healthy controls (HC) matched for gender, age and education participated in this study. All subjects underwent diffusion tensor imaging (DTI), and were assessed with the 17 item hamilton depression rating scale (HAMD-17) and hamilton anxiety rating scale (HAMA). Properties of brain network were examined by the method of graph-theoretic analysis. The assessments included small-worldness, clustering coefficient and shortest path length.
resultsNSCLC patients had higher scores of HAMD-17 and HAMA when compared with HC. Additionally, we found a small-world topology of brain white matter network in both NSCLC and HC. NSCLC patients had significantly reduced clustering coefficient compared to healthy controls in the left hippocampus. Moreover, increased shortest path length were identified in NSCLC patients, which included the left middle frontal gyrus (orbital part), superior temporal gyrus and right Rolandic operculum, rectus gyrus, lenticular nucleus (putamen). However, no correlations were found between the impaired brain regions and HAMD-17, HAMA scores of NSCLC patients.
conclusionsOur results indicated impaired topological characteristics in the brain structural network of non-nervous system metastatic NSCLC patients prior to chemotherapy, which might account for the cancer-related emotional distress. Our findings demonstrated that NSCLC might affect brain regions involved in the process of emotion, which identified the basis of emotional changes associated with cancer.
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