Evidence map›Paper›PMID 32953277›Full record

ArticlePeerJ2020

Platelet factor 4 inhibits human hair follicle growth and promotes androgen receptor expression in human dermal papilla cells.

Ke Sha, Mengting Chen, Fangfen Liu, San Xu, Ben Wang, Qinqin Peng, Yiya Zhang, Hongfu Xie, Ji Li, Zhili Deng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PeerJ, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Ke ShaDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Mengting ChenDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Fangfen LiuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
San XuDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Ben WangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Qinqin PengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Yiya ZhangDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Hongfu XieDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Ji LiDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Zhili DengDepartment of Dermatology, Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNXiangya Hospital Central South University · CNNational Clinical Research · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Platelet-rich plasma (PRP) has been reported recently as a potential therapeutic approach for alopecia, such as androgenetic alopecia, but the exact mechanisms and effects of specific components of this recipe remain largely unknown. In this study, we identified that platelet factor 4 (PF4), a component of PRP, significantly suppressed human hair follicle growth and restrained the proliferation of human dermal papilla cells (hDPCs). Furthermore, our results showed that PF4 upregulated androgen receptor (AR) in human dermal papilla cells

Indexed as

Androgen receptorDermal papilla cellsHair follicleHair lossPlatelet factor 4Platelet-rich plasma

Identifiers

PMID32953277
PMCPMC7476492
OpenAlexW3083434803

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.