Evidence map›Paper›PMID 32953229›Full record

Trial reportPediatric allergy, immunology, and pulmonology2020

Long-Term Efficacy of Subcutaneous C1 Inhibitor in Pediatric Patients with Hereditary Angioedema.

Donald Levy, Teresa Caballero, Iftikhar Hussain, Avner Reshef, John Anderson, James Baker, Lawrence B Schwartz, Marco Cicardi, Subhransu Prusty, Henrike Feuersenger and 2 more

Open access · hybridAbstract readClinical Trial, Phase IIIMulticenter StudyRandomized Controlled Trial
In one paragraph

Trial report in Pediatric allergy, immunology, and pulmonology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 5 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 5 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Interventions for the long-term prevention of hereditary angioedema attacks.The Cochrane database of systematic reviews · 2022
    Pooled it
  6. The International/Canadian hereditary angioedema guideline.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2026
    Review
  7. Hereditary angioedema in children: Review and practical perspective for clinical management.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024
    Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Donald LevyUniversity of California at Irvine, Irvine, California, USA.
Teresa CaballeroHospital Universitario La Paz, Madrid, Spain.
Iftikhar HussainVital Prospects Clinical Research Institute, Tulsa, Oklahoma, USA.
Avner ReshefBarzilai Medical Centre, Ashkelon, Israel.
John AndersonClinical Research Center of Alabama, Birmingham, Alabama, USA.
James BakerBaker Allergy, Asthma and Dermatology Research Center, Portland, Oregon, USA.
Lawrence B SchwartzVirginia Commonwealth University, Richmond, Virginia, USA.
Marco CicardiUniversity of Milan, Milan, Italy.
Subhransu PrustyCSL Behring GmbH Standort Behringwerke Marburg, Marburg, Germany.
Henrike FeuersengerCSL Behring GmbH Standort Behringwerke Marburg, Marburg, Germany.
Ingo PragstCSL Behring GmbH Standort Behringwerke Marburg, Marburg, Germany.
Michael E ManningMedical Research of Arizona, Scottadale, Arizona, USA.
Barzilai Medical Center · ILHospital Universitario La Paz · ESUniversity of California, Irvine · USUniversity of Milan · ITVirginia Commonwealth University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AdolescentAngioedemas, HereditaryChildComplement C1 Inhibitor ProteinDisease ProgressionDose-Response Relationship, DrugDrug Administration ScheduleFemaleHumansInjections, SubcutaneousMaleSeverity of Illness IndexTime FactorsTreatment OutcomeComplement C1 Inhibitor ProteinSERPING1 protein, humanC1 inhibitorchildrenCOMPACTHaegardahereditary angioedemalong termpediatricprophylaxisquality of lifesafety

Identifiers

PMID32953229
PMCPMC7499895
OpenAlexW3087080946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.