Evidence map›Paper›PMID 32953038›Full record

ArticleStroke research and treatment2020

Cerebral Venous Sinus Thrombosis in Women: Subgroup Analysis of the VENOST Study.

Derya Uluduz, Sevki Sahin, Taskin Duman, Serefnur Ozturk, Vildan Yayla, Nazire Afsar, Nevzat Uzuner, Ipek Midi, Nilgun Cinar, Mehmet Ali Sungur and 43 more

Open access · goldAbstract read
In one paragraph

Article in Stroke research and treatment, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

  1. Cerebrovascular and Peripheral Vascular Complications in Cancer Patients.Current neurology and neuroscience reports · 2025
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  9. Clinical Values of Coagulation Factors X, XI, and XII in Cerebral Venous Sinus Thrombosis During Perinatal State.Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

53 authors at 20 institutions in 2 countries.

Derya UluduzSchool of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3811-5017
Sevki SahinSchool of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-2016-9965
Taskin DumanSchool of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey.ORCID https://orcid.org/0000-0002-6552-4193
Serefnur OzturkSelcuk University, School of Medicine, Department of Neurology, Konya, Turkey.ORCID https://orcid.org/0000-0001-8986-155X
Vildan YaylaUniversity of Health Science, Hamidiye School of Medicine, Sadi Konuk Research and Training Hospital, Department of Neurology, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-4188-0898
Nazire AfsarAcibadem University, School of Medicine, Department of Neurology, Istanbul, Turkey.ORCID https://orcid.org/0000-0001-8123-8560
Nevzat UzunerOsmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey.ORCID https://orcid.org/0000-0002-4961-4332
Ipek MidiMarmara University, School of Medicine, Department of Neurology, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-5125-3708
Nilgun CinarSchool of Medicine, Department of Neurology, Maltepe University, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3868-3137
Mehmet Ali SungurDuzce University, School of Medicine, Department of Biostatistics, Duzce, Turkey.ORCID https://orcid.org/0000-0001-5380-0819
Fusun Mayda DomacUniversity of Health Science, Hamidiye School of Medicine, Erenkoy Research and Training Hospital for Neurologic and Psychiatric Diseases, Department of Neurology, Istanbul, Turkey.ORCID https://orcid.org/0000-0003-3576-0344
Birsen InceSchool of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey.
Baki GoksanSchool of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey.
Cemile Handan MisirliUniversity of Health Science, Hamidiye School of Medicine, Haydarpasa Training and Research Hospital, Department of Neurology, Istanbul, Turkey.
Mustafa BakarUludag University, School of Medicine, Department of Neurology, Bursa, Turkey.
Hasan Huseyin KozakNemettin Erbakan University, School of Medicine, Department of Neurology, Konya, Turkey.
Sena ColakogluSchool of Medicine, Department of Neurology, Mustafa Kemal University, Hatay, Turkey.
Ali Yavuz KarahanUsak University, School of Medicine, Department of Physical Medicine and Rehabilitation, Usak, Turkey.ORCID https://orcid.org/0000-0001-8142-913X
Eylem Ozaydin GoksuAntalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey.
Fatih OzdagUniversity of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey.
Mehmet Guney SenolUniversity of Health Science, Hamidiye School of Medicine, Sultan Abdulhamid Han Research and Training Hospital, Department of Neurology, Istanbul, Turkey.
Vedat Ali YurekliSuleyman Demirel University, School of Medicine, Department of Neurology, Isparta, Turkey.
Ufuk AlucluDicle University, School of Medicine, Department of Neurology, Diyarbakır, Turkey.
Serkan DemirSancaktepe Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey.
Hayriye KucukogluSultan Abdulhamid Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey.
Serdar OrucKocatepe University, School of Medicine, Department of Neurology, Afyon, Turkey.
Nilufer YesilotIstanbul University, School of Medicine, Department of Neurology, Istanbul, Turkey.
Ozge Yimaz KusbeciBozyaka Education, Research and Traning Hospital, Clinic of Neurology, Izmir, Turkey.
Bijen NazlielGazi University, School of Medicine, Department of Neurology, Ankara, Turkey.ORCID https://orcid.org/0000-0002-6148-3814
Firdevs Ezgi Ucan TokucAntalya Research and Training Hospital, Clinic of Neurology, Antalya, Turkey.
Hesna BektasAtaturk Research and Training Hospital, Clinic of Neurology, Ankara, Turkey.
Fatma Nida TascilarBulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey.
Emrah AytacFirat University, School of Medicine, Department of Neurology, Elazig, Turkey.
Mustafa GokceSutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey.
Hale Zeynep Batur CaglayanGazi University, School of Medicine, Department of Neurology, Ankara, Turkey.
Ahmet TufekciRecep Tayyip Erdogan University, School of Medicine, Department of Neurology, Rize, Turkey.
Gulnur UzunerOsmangazi University, School of Medicine, Department of Neurology, Eskisehir, Turkey.
Dilek Necioglu OrkenBilim University, School of Medicine, Department of Neurology, Istanbul, Turkey.
Osman Ozgur YalinIstanbul Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey.
Uygar UtkuSutcu Imam University, School of Medicine, Department of Neurology, Kahramanmaras, Turkey.
Arda YilmazMersin University, School of Medicine, Department of Neurology, Mersin, Turkey.
Hamit GencMersin University, School of Medicine, Department of Neurology, Mersin, Turkey.
Murat CabalarSadi Konuk Research and Training Hospital, Clinic of Neurology, Istanbul, Turkey.
Aysel MilanliogluYuzuncu Yil University, School of Medicine, Department of Neurology, Van, Turkey.
Hakan EkmekciSelcuk University, School of Medicine, Department of Neurology, Konya, Turkey.
Burcu ZeydanMayo Clinic, College of Medicine, Department of Neurology, Rochester, MN., USA.
Sevim BaybasBakirkoy Prof. Dr. Mazhar Osman Mental Health and Neurology Training and Research Hospital, Clinic of Neurology, Istanbul, Turkey.
Yuksel KablanInonu University, School of Medicine, Department of Neurology, Malatya, Turkey.
Basak Karakurum GokselBaskent University, School of Medicine, Department of Neurology, Ankara, Turkey.
Mustafa AcikgozBulent Ecevit University, School of Medicine, Department of Neurology, Zonguldak, Turkey.
Hatice KurucuSchool of Medicine, Department of Neurology, Istanbul Cerrahpasa University, Istanbul, Turkey.
Seden DemirciAkdeniz University, School of Medicine, Department of Neurology, Antalya, Turkey.
Taskin GunesMaltepe Government Hospital, Clinic of Neurology, Istanbul, Turkey.
Sağlık Bilimleri Üniversitesi · TRMaltepe University · TRAntalya Eğitim ve Araştırma Hastanesi · TRBakırköy Dr.Sadi Konuk Eğitim ve Araştırma Hastanesi · TRBülent Ecevit University · TREskişehir Osmangazi University · TRGazi University · TRKahramanmaraş Sütçü İmam University · TRMersin Üniversitesi · TRMustafa Kemal University · TRSelçuk University · TRAcıbadem University · TRAfyon Kocatepe University · TRAkdeniz University · TRAnkara Atatürk Eğitim ve Araştırma Hastanesi · TRBakırköy Psychiatric Hospital · TRBaşkent University · TRBursa Uludağ Üni̇versi̇tesi̇ · TRDicle University · TRDüzce Üniversitesi · TR

Funding

Sex-Specific Effects of Endocrine Disruption on Aging and Alzheimer's DiseaseU54AG044170 · NIA · MAYO CLINIC ROCHESTER · PI KANTARCI, KEJAL, MIELKE, MICHELLE M · 2018 to 2022
$7.7M
6 · The paper itself

Abstract

backgroundEarly diagnosis of cerebral venous sinus thrombosis (CVST) associated with reproductive health-related risk factors (RHRF) including pregnancy, puerperium, and oral contraceptive (OC) use can prevent severe neurological sequelae; thus, the symptoms must be documented in detail for each group.

methodsOut of 1144 patients with CVST, a total of 777 women were enrolled from a multicenter for the study of cerebral venous sinus thrombosis (VENOST). Demographic, biochemical, clinical, and radiological aspects were compared for 324 cases with RHRF and 453 cases without RHRF.

resultsThe mean age of the RHRF (-) group (43.2 ± 13 years) was significantly higher than of the RHRF (+) group (34 ± 9 years). A previous history of deep venous thrombosis (3%), isolated cavernous sinus involvement (1%), cranial neuropathy (13%), comorbid malignancy (7%), and its disability scores after 12 months (9%) were significantly higher in the RHRF (-) group. The RHRF (+) group consisted of 44% cases of puerperium, 33% cases of OC users and 23% of pregnant women. The mean age was found to be higher in OC users (38 ± 9 years). A previous history of deep venous thrombosis was slightly higher in the pregnancy subgroup (4%). Epileptic seizures were more common in the puerperium group (44%).

conclusionThe results of our study indicate that the risk of CSVT increases parallel to age, OC use, and puerperium period. In addition, when considering the frequency of findings and symptoms, epileptic seizures in the puerperium subgroup of the RHRF (+) group and malignancies in the RHRF (-) group may accompany the CSVT. In daily practice, predicting these risks for the CSVT and early recognition of the symptoms will provide significant benefits to patients.

Identifiers

PMID32953038
PMCPMC7481993
OpenAlexW3081910737

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.