Evidence map›Paper›PMID 32953015›Full record

ArticleChemical science2020

A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease.

Yuehua Chen, Yuzhu Wang, Yonggang Yang, Yuhuan Li, Yafu Wang, Ge Wang, Tony D James, Xiaopeng Xuan, Hua Zhang, Yufang Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemical science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. A de novo strategy to develop NIR precipitating fluorochrome for long-term in situ cell membrane bioimaging.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuehua ChenHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.
Yuzhu WangDepartment of Hepatobiliary and Pancreatic Surgery , Henan Provincial People's Hospital , Zhengzhou University People's Hospital , Henan University People's Hospital , Zhengzhou , Henan 450003 , P. R. China.ORCID 0000-0002-7504-6033
Yonggang YangHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.
Yuhuan LiHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.
Yafu WangHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.
Ge WangXinxiang Medical University , Xinxiang 453000 , P. R. China.
Tony D JamesHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.ORCID 0000-0002-4095-2191
Xiaopeng XuanHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.
Hua ZhangHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.ORCID 0000-0002-7593-4946
Yufang LiuHenan Key Laboratory of Green Chemical Media and Reactions , Ministry of Education , Henan Key Laboratory of Organic Functional Molecules and Drug Innovation , School of Chemistry and Chemical Engineering , School of Physics , Henan Normal University , Xinxiang 453007 , P. R. China . Email: zhanghua1106@163.com.ORCID 0000-0003-1896-8864

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lighting up the relevant lesion boundaries during operations is vital for guiding the effective resection of hepatopathic tissue. We envisioned that molecular-logic gates, which are known for their excellent digital correlation between input and output signals, could be used to facilitate differential visualization of lesion boundaries. Herein, a series of flexible molecules, naphthalene imide-indole derivatives (

Identifiers

PMID32953015
PMCPMC7480271

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.