Evidence map›Paper›PMID 32952999›Full record

ArticleMedChemComm2019

Selective

Ryan J O Nichol, Abedawn I Khalaf, Kartheek Sooda, Omar Hussain, Hollie B S Griffiths, Roger Phillips, Farideh A Javid, Colin J Suckling, Simon J Allison, Fraser J Scott

Open access · greenAbstract read
In one paragraph

Article in MedChemComm, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ryan J O NicholDepartment of Biological and Geographical Sciences , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.
Abedawn I KhalafDepartment of Pure and Applied Chemistry , WestCHEM , University of Strathclyde , Glasgow , UK . Email: fraser.j.scott@strath.ac.uk.ORCID 0000-0001-9162-7527
Kartheek SoodaDepartment of Pharmacy , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.
Omar HussainDepartment of Pharmacy , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.
Hollie B S GriffithsDepartment of Biological and Geographical Sciences , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.
Roger PhillipsDepartment of Pharmacy , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.ORCID 0000-0003-3504-177X
Farideh A JavidDepartment of Pharmacy , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.ORCID 0000-0002-2775-6276
Colin J SucklingDepartment of Pure and Applied Chemistry , WestCHEM , University of Strathclyde , Glasgow , UK . Email: fraser.j.scott@strath.ac.uk.
Simon J AllisonDepartment of Biological and Geographical Sciences , School of Applied Sciences , University of Huddersfield , Huddersfield , UK.ORCID 0000-0002-5766-2377
Fraser J ScottDepartment of Pure and Applied Chemistry , WestCHEM , University of Strathclyde , Glasgow , UK . Email: fraser.j.scott@strath.ac.uk.ORCID 0000-0003-0229-3698
University of Huddersfield · GBUniversity of Strathclyde · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traditional cytotoxic agents which act through a DNA-alkylating mechanism are relatively non-specific, resulting in a small therapeutic window and thus limiting their effectiveness. In this study, we evaluate a panel of 24 non-alkylating Strathclyde Minor Groove Binders (S-MGBs), including 14 novel compounds, for

Identifiers

PMID32952999
PMCPMC7478159
OpenAlexW2956943766

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.