ArticleIndian journal of orthopaedics2020
Morphological Alteration and TGF-β1 Expression in Multifidus with Lumbar Disc Herniation.
Article in Indian journal of orthopaedics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 8 citations in OpenAlex.
- A review and empirical findings of fasciae and muscle interactions in low back pain.Frontiers in physiology · 2025Article
- Correlation between inflammatory cytokine expression in paraspinal tissues and severity of disc degeneration in individuals with lumbar disc herniation.BMC musculoskeletal disorders · 2023Article
- Spinal degeneration is associated with lumbar multifidus morphology in secondary care patients with low back or leg pain.Scientific reports · 2022Article
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5 authors at 4 institutions in 1 country.
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Abstract
backgroundLumbar disc herniation (LDH) can cause lumbar nerve root compression, which can lead to denervated atrophy of paraspinal muscles theoretically, however, the conclusions of morphological alteration in multifidus with LDH remain controversial. Transforming growth factor-beta 1 (TGF-β1) plays an essential role in the development of tissue fibrosis and is a molecular marker in the study of muscle fibrosis, but no relevant studies on TGF-β1 expression in multifidus have been reported so far. This study is to observe altered morphology of multifidus in patients with LDH, and to explore the correlation between multifidus fibrosis and TGF-β1 expression. MATERIALS AND
methods46 LDH patients with low back pain combined with unilateral leg radiation pain and/or numbness were selected. Patients were divided into four groups according to their medical histories. Group 1: medical history less than 6 months (15 cases); group 2: a medical history of 6-12 months (10 cases); group 3: a medical history of 12-24 months (13 cases); and group 4: medical history > 24 months (8 cases). Bilateral multifidus specimens were taken from compressed nerve root segments, and morphological changes in multifidus were determined. Multi-parameter changes in TGF-β1 expression in multifidus were observed by immunohistochemistry and immunofluorescence.
resultsHE staining showed that the cross-sectional area (CSA) of multifidus in the involved sides decreased and muscle fibers atrophied. Masson's trichrome staining showed a decrease in the sectional area ratio of myofibers to collagen fibers in the involved side. In groups 1 and 2, there were no significant differences in the aforementioned parameters. In groups 3 and 4, statistically significant differences in the sectional area ratio of myofibers to collagen fibers in both sides were seen (
conclusionsNerve root compression by LDH leads to multifidus atrophy, fibrosis, and increased TGF-β1 expression, which might promote multifidus fibrosis.
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