Evidence map›Paper›PMID 32952734›Full record

ReviewCellular and molecular bioengineering2020

Organoids as Complex

Benjamin C Hacker, Marjan Rafat

Abstract readReview
In one paragraph

Review in Cellular and molecular bioengineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. iScience · 2023
    Article
  7. Article
  8. Article
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Benjamin C HackerDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN USA.
Marjan RafatDepartment of Chemical and Biomolecular Engineering, Vanderbilt University, Nashville, TN USA.ORCID 0000-0002-9444-4379

Funding

Deconstructing the Tumor Microenvironment and its Role in MetastasisR00CA201304 · NCI · VANDERBILT UNIVERSITY · PI RAFAT, MARJAN · 2018 to 2020
$728k
NCI NIH HHS R00 CA201304
6 · The paper itself

Abstract

Patients with triple negative breast cancer (TNBC) typically receive chemotherapy, surgery, and radiation therapy. Although this treatment improves prognosis for most patients, some patients continue to experience recurrence within 5 years. Preclinical studies have shown that immune cell infiltration at the irradiated site may play a significant role in tumor cell recruitment; however, little is known about the mechanisms that govern this process. This lack of knowledge highlights the need to evaluate radiation-induced cell infiltration with models that have controllable variables and maintain biological integrity. Mammary organoids are multicellular three-dimensional (3D)

Indexed as

Cell–cell interactionsimmune cell co-cultureionizing radiationorganoid modelsradiotherapyrecurrencetriple negative breast cancer

Identifiers

PMID32952734
PMCPMC7479086

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.