ReviewBeilstein journal of organic chemistry2020
Photosensitized direct C-H fluorination and trifluoromethylation in organic synthesis.
Review in Beilstein journal of organic chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed.
- Non-decarboxylative C-H Fluorination of Carboxylic Acids by Iridium Photocatalysis.Organic letters · 2026Article
- A study towards the undirected fluorination and chlorination of cubane 1,4-diester.Beilstein journal of organic chemistry · 2026Article
- Protodefluorinated SelectfluorChemSusChem · 2024Article
- The rat acute oral toxicity of trifluoromethyl compounds (TFMs): a computational toxicology study combining the 2D-QSTR, read-across and consensus modeling methods.Archives of toxicology · 2024Article
- Pulsed electrolysis: enhancing primary benzylic C(spOrganic chemistry frontiers : an international journal of organic chemistry · 2024Article
- Benzylic C(spBeilstein journal of organic chemistry · 2024Review
- Reactive fragments targeting carboxylate residues employing direct to biology, high-throughput chemistry.RSC medicinal chemistry · 2023Article
- Benzoates as photosensitization catalysts and auxiliaries in efficient, practical, light-powered direct C(spChemical science · 2022Article
- Radical hydrodifluoromethylation of unsaturated C-C bonds via an electroreductively triggered two-pronged approach.Communications chemistry · 2022Article
- α-Amino Radical Halogen Atom Transfer Agents for Metallaphotoredox-Catalyzed Cross-Electrophile Couplings of Distinct Organic Halides.ChemSusChem · 2022Article
- Synthetic Molecular Photoelectrochemistry: New Frontiers in Synthetic Applications, Mechanistic Insights and Scalability.Angewandte Chemie (International ed. in English) · 2022Review
- Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry.Chemical reviews · 2022Review
- Direct Photocatalyzed Hydrogen Atom Transfer (HAT) for Aliphatic C-H Bonds Elaboration.Chemical reviews · 2022Review
- Electro-mediated PhotoRedox Catalysis for Selective C(spAngewandte Chemie (International ed. in English) · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of fluorinated products in pharmaceutical and medicinal chemistry has necessitated the development of synthetic fluorination methods, of which direct C-H fluorination is among the most powerful. Despite the challenges and limitations associated with the direct fluorination of unactivated C-H bonds, appreciable advancements in manipulating the selectivity and reactivity have been made, especially via transition metal catalysis and photochemistry. Where transition metal catalysis provides one strategy for C-H bond activation, transition-metal-free photochemical C-H fluorination can provide a complementary selectivity via a radical mechanism that proceeds under milder conditions than thermal radical activation methods. One exciting development in C-F bond formation is the use of small-molecule photosensitizers, allowing the reactions i) to proceed under mild conditions, ii) to be user-friendly, iii) to be cost-effective and iv) to be more amenable to scalability than typical photoredox-catalyzed methods. In this review, we highlight photosensitized C-H fluorination as a recent strategy for the direct and remote activation of C-H (especially C(sp
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.