Evidence map›Paper›PMID 32952587›Full record

ArticleEvidence-based complementary and alternative medicine : eCAM2020

Electroacupuncture Alleviates Osteoarthritis by Suppressing NLRP3 Inflammasome Activation in Guinea Pigs.

Zhankui Wang, Mo Chen, Bo Wang, Wulin Kang, Hongchao Yu, Xiaoqun Li, Bo Dong, Puwei Yuan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Evidence-based complementary and alternative medicine : eCAM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 3 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 16 citations in OpenAlex.

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  16. Electroacupuncture Upregulates HIF-1Evidence-based complementary and alternative medicine : eCAM · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhankui WangDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Mo ChenDepartment of Anesthesiology, Suzhou Municipal Hospital (North District), Nanjing Medical University Affiliated Suzhou Hospital, Suzhou 215008, Jiangsu, China.
Bo WangDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Wulin KangDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Hongchao YuDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Xiaoqun LiDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.
Bo DongDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.ORCID https://orcid.org/0000-0003-4715-0973
Puwei YuanDepartment of Orthopedics, The First Clinical Medical College, Shaanxi University of Chinese Medicine, Xianyang 712046, Shaanxi, China.ORCID https://orcid.org/0000-0001-7916-8823
Shaanxi University of Chinese Medicine · CNSuzhou Municipal Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Osteoarthritis (OA) is an increasingly prevalent disease affecting synovial joints, which includes joint degeneration, inflammation, and joint pain. The activation of nucleotide-binding and oligomerization domain-like receptor containing protein 3 (NLRP3) could promote synovial inflammation. Previous studies have shown that electroacupuncture (EA) has potential anti-inflammatory effect. However, the effect of EA treatment on OA remains unclear. The aim of this study was to investigate the effect of applied EA on OA and joint pain and its relationship with NLRP3 inflammasome. The Hartley guinea pigs with naturally occurring OA at age 18 months were chosen as the OA model and treated with EA for 4 weeks. Mechanical allodynia was quantified by using von Frey filaments. The expression of NLRP3 inflammasome and the downstream proinflammatory factors in the cartilage tissue were quantified. Our results showed that EA treatment significantly reduces mechanical allodynia, improves the articular cartilage structure, and decreases the fibrillation on the cartilage surface in guinea pigs with spontaneous osteoarthritis. Moreover, we also found that EA treatment attenuates the NLRP3 inflammasome activation and suppresses the protein expression levels of caspase-1 and IL-1

Identifiers

PMID32952587
PMCPMC7487102
OpenAlexW3083595152

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.