Evidence map›Paper›PMID 32952569›Full record

ArticleStem cells international2020

Susceptibility to Ventricular Arrhythmias Resulting from Mutations in

Hector Barajas-Martinez, Maya Smith, Dan Hu, Robert J Goodrow, Colleen Puleo, Can Hasdemir, Charles Antzelevitch, Ryan Pfeiffer, Jacqueline A Treat, Jonathan M Cordeiro

Open access · goldAbstract read
In one paragraph

Article in Stem cells international, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Primary Electrical Heart Disease-Principles of Pathophysiology and Genetics.International journal of molecular sciences · 2024
    Review
  5. Article
  6. Review
  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

Hector Barajas-MartinezDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.ORCID https://orcid.org/0000-0002-2704-3807
Maya SmithDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Dan HuDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Robert J GoodrowDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Colleen PuleoDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Can HasdemirDepartment of Cardiology, Ege University School of Medicine, Izmir, Turkey.
Charles AntzelevitchDepartment of Cardiovascular Research, Lakenau Institute for Medical Research, Wynnewood, PA, USA.
Ryan PfeifferDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Jacqueline A TreatDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.
Jonathan M CordeiroDepartment of Experimental Cardiology, Masonic Medical Research Institute, Utica, NY, USA.ORCID https://orcid.org/0000-0002-4311-4599
Masonic Medical Research Laboratory · USEge University · TRLankenau Institute for Medical Research · USThomas Jefferson University · USWuhan University · CN

Funding

ELECTRICAL HETEROGENEITY AND CARDIAC ARRHYTHMIASR01HL047678 · NHLBI · MASONIC MEDICAL RESEARCH LABORATORY, INC · PI ANTZELEVITCH, CHARLES · 1993 to 2014
$5.7M
Development of a whole heart model of the J wave syndromes and novel approaches to pharmacologic management of associated life-threatening arrhythmiasR01HL152201 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES, DI DIEGO, JOSE M. · 2020 to 2023
$2.5M
Novel Approaches to Pharmacologic Management of Life-Threatening Arrhythmias Associated with the J Wave SyndromesR56HL138103 · NHLBI · LANKENAU INSTITUTE FOR MEDICAL RESEARCH · PI ANTZELEVITCH, CHARLES · 2018 to 2018
$413k
Arrhythmia mechanisms in Long QT SyndromeR15HL145530 · NHLBI · NORFOLK STATE UNIVERSITY · PI MARZ, AYLIN · 2019 to 2019
$379k
NHLBI NIH HHS R01 HL047678NHLBI NIH HHS R01 HL152201NHLBI NIH HHS R15 HL145530NHLBI NIH HHS R56 HL138103
6 · The paper itself

Abstract

backgroundWe report an inherited cardiac arrhythmia syndrome consisting of Brugada and Early Repolarization Syndrome associated with variants in METHODS AND

resultsWe assessed the functional impact of these mutations in induced pluripotent stem cell cardiomyocytes (hiPSC-CMs) derived from the proband and an unaffected family member. Current and voltage clamp recordings, as well as confocal microscopy analysis of Ca

conclusion

Identifiers

PMID32952569
PMCPMC7481990
OpenAlexW3082275092

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.